Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | STAT6 | P42226 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | NTSR1 | P30989 | 6/20 | 0.41 |
| ▸ | ABCG2 | Q9UNQ0 | 4/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16183252 | 0.93 | KDM4E (0.43) | KDM4ESTAT6NPSR1NTSR1ABCG2 | |
| SCHEMBL14474741 | 0.90 | MAPT (0.41) | KDM4ENPSR1LMNAMAPTCYP1A2 | |
| SCHEMBL16183253 | 0.87 | KDM4E (0.41) | KDM4ESTAT6NPSR1NTSR1ABCG2 | |
| SCHEMBL14474744 | 0.83 | MAPT (0.41) | KDM4ENPSR1LMNAMAPTTSHR | |
| SCHEMBL16184702 | 0.83 | MAPT (0.44) | KDM4ENPSR1LMNAMAPTHTT | |
| SCHEMBL14475266 | 0.83 | MAPT (0.41) | KDM4ENPSR1LMNAMAPTCYP1A2 | |
| SCHEMBL16184060 | 0.79 | MAPT (0.43) | KDM4ENPSR1ABCG2LMNAMAPT | |
| SCHEMBL16184785 | 0.78 | MAPT (0.48) | KDM4ENPSR1LMNAMAPTGBA1 | |
| SCHEMBL16184780 | 0.78 | MAPT (0.45) | KDM4ESTAT6NPSR1NTSR1LMNA | |
| SCHEMBL16184770 | 0.78 | MAPT (0.47) | KDM4ESTAT6NPSR1NTSR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140315886-A1 | QUINAZOLINES AS THERAPEUTIC COMPOUNDS AND RELATED METHODS OF USE | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2014-10-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140315886-A1 | QUINAZOLINES AS THERAPEUTIC COMPOUNDS AND RELATED METHODS OF USE | PPP2CA, PPP4C, PPP3CB | KDM4E 1395/4885STAT6 2283/4885NPSR1 455/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.