SCHEMBL1447729

SCHEMBL1447729

CCC[CH]c1ccncc1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 4/20 0.38
SMN1; SMN2 Q16637 3/20 0.38
CISD1 Q9NZ45 2/20 0.38
NPC1 O15118 2/20 0.38
RAB9A P51151 2/20 0.38
CYP1A2 P05177 2/20 0.38
CYP3A4 P08684 2/20 0.38
CYP2D6 P10635 2/20 0.38
HPGD P15428 2/20 0.38
MEN1 O00255 1/20 0.38
ALOX15 P16050 1/20 0.38
CASP1 P29466 1/20 0.38
HBB P68871 1/20 0.38
KMT2A Q03164 1/20 0.38
KDM4E B2RXH2 1/20 0.38
CYP2C9 P11712 1/20 0.38
CYP2C19 P33261 1/20 0.38
ALDH1A1 P00352 2/20 0.36
MAOA P21397 1/20 0.36
MAOB P27338 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8200303 0.86 MAPT (0.44) MAPTSMN1; SMN2CISD1NPC1RAB9A
SCHEMBL7296109 0.85 MAPT (0.46) MAPTSMN1; SMN2CISD1NPC1RAB9A
SCHEMBL8200101 0.83 MAPT (0.49) MAPTSMN1; SMN2NPC1CYP3A4CYP2D6
SCHEMBL27772342 0.83 MAPT (0.49) MAPTSMN1; SMN2NPC1CYP3A4CYP2D6
SCHEMBL27772351 0.83 MAPT (0.49) MAPTSMN1; SMN2NPC1CYP3A4CYP2D6
SCHEMBL8200154 0.83 MAPT (0.49) MAPTSMN1; SMN2NPC1CYP3A4CYP2D6
SCHEMBL8200117 0.83 MAPT (0.49) MAPTSMN1; SMN2NPC1CYP3A4CYP2D6
SCHEMBL27751551 0.83 MAPT (0.49) MAPTSMN1; SMN2NPC1CYP3A4CYP2D6
SCHEMBL8204698 0.83 MAPT (0.49) MAPTSMN1; SMN2NPC1CYP3A4CYP2D6
SCHEMBL288700 0.82

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6399582-B1 GASTROINTESTINAL DISORDERS ORTHO-MCNEIL PHARMACEUTICAL, INC. 2002-06-04 US claimed
EP-1171447-A2 KETOLIDE ANTIBACTERIALS Ortho-McNeil Pharmaceutical, Inc. (US) 2002-01-16 EP claimed
WO-2000062783-A2 KETOLIDE ANTIBACTERIALS ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) 2000-10-26 WO claimed
EP-3666757-A1 PROCESS FOR PREPARING A PIPERIDIN-4-ONE Karl-Franzens-Universität Graz (AT) 2020-06-17 EP disclosed
WO-2011035355-A1 NOVEL ANTIMALARIAL 3-AZABICYCLO[3.2.2]NONANE DERIVATIVES UNIVERSITY OF GRAZ (AT) 2011-03-31 WO disclosed
EP-2301627-A1 Novel antimalarial 3-azabicyclo[3.2.2]nonane derivatives University of Graz (AT) 2011-03-30 EP disclosed
US-6815183-B1 Plasmodium sp. chitinase THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM 2004-11-09 US disclosed
EP-1345953-A2 KETOLIDE ANTIBACTERIALS Ortho-Mcneil Pharmaceutical, Inc. (US) 2003-09-24 EP disclosed
US-6590083-B1 Compounds of given formula; erythromycin derivatives; useful in the treatment of bacterial and protozoal infections and conditions involving gastric motility ORTHO-MCNEIL PHARMACEUTICAL, INC. 2003-07-08 US disclosed
US-6458771-B1 SERIES OF KETOLIDE ANTIBACTERIALS IN THE MACROLIDE FAMILY, DRUGS AND INTERMEDIATES, ERYTHROMYCIN ANALOGUES USEFUL IN THE TREATMENT OF BACTERIAL AND PROTOZOAL INFECTIONS AND IN THE TREATMENT OF GASTRIC MOTILITY ORTHO-MCNEIL PHARMACEUTICAL, INC. 2002-10-01 US disclosed
US-6399582-B1 GASTROINTESTINAL DISORDERS ORTHO-MCNEIL PHARMACEUTICAL, INC. 2002-06-04 US disclosed
WO-2002032918-A2 KETOLIDE ANTIBACTERIALS ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) 2002-04-25 WO disclosed
EP-1171447-A2 KETOLIDE ANTIBACTERIALS Ortho-McNeil Pharmaceutical, Inc. (US) 2002-01-16 EP disclosed
WO-2000062783-A2 KETOLIDE ANTIBACTERIALS ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) 2000-10-26 WO disclosed
US-6043227-A C11 carbamates of macrolide antibacterials PFIZER INC. (US) 2000-03-28 US disclosed