Sennoside B

Sennoside B

SCHEMBL14477483

O=C(O)c1cc(O)c2c(c1)[C@H]([C@H]1c3cc(C(=O)O)cc(O)c3C(=O)c3c(O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)cccc31)c1cccc(OC3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)c1C2=O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ USP2 O75604 4/20 1.00
▸ HKDC1 Q2TB90 3/20 1.00
▸ L3MBTL1 Q9Y468 3/20 1.00
▸ TDP1 Q9NUW8 3/20 1.00
▸ KDM4E B2RXH2 3/20 1.00
▸ MAPT P10636 3/20 1.00
▸ TNNI3 P19429 2/20 1.00
▸ TNNT2 P45379 2/20 1.00
▸ TNNC1 P63316 2/20 1.00
▸ MEN1 O00255 2/20 1.00
▸ CYP3A4 P08684 2/20 1.00
▸ MAPK1 P28482 2/20 1.00
▸ RECQL P46063 2/20 1.00
▸ KMT2A Q03164 2/20 1.00
▸ NPC1 O15118 1/20 1.00
▸ RAB9A P51151 1/20 1.00
▸ LMNA P02545 1/20 1.00
▸ GLA P06280 1/20 1.00
▸ THRB P10828 1/20 1.00
▸ HPGD P15428 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Sennoside B SCHEMBL13287144 1.00 USP2 (1.00) USP2HKDC1L3MBTL1TDP1KDM4E
Sennoside B SCHEMBL17131971 1.00 USP2 (1.00) USP2HKDC1L3MBTL1TDP1KDM4E
Sennoside B SCHEMBL17131970 1.00 USP2 (1.00) USP2HKDC1L3MBTL1TDP1KDM4E
Sennoside B SCHEMBL14478776 1.00 USP2 (1.00) USP2HKDC1L3MBTL1TDP1KDM4E
Sennoside B SCHEMBL14355960 1.00 USP2 (1.00) USP2HKDC1L3MBTL1TDP1KDM4E
Sennoside B SCHEMBL23685626 1.00 USP2 (1.00) USP2HKDC1L3MBTL1TDP1KDM4E
Sennoside B SCHEMBL17131813 1.00 USP2 (1.00) USP2HKDC1L3MBTL1TDP1KDM4E
Sennoside B SCHEMBL14353400 1.00 USP2 (1.00) USP2HKDC1L3MBTL1TDP1KDM4E
Sennoside A,B SCHEMBL20822082 1.00 USP2 (1.00) USP2HKDC1L3MBTL1TDP1KDM4E
Sennoside B SCHEMBL441194 1.00 USP2 (1.00) USP2HKDC1L3MBTL1TDP1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10959979-B2 Small molecules against cancer BIOKINE THERAPEUTICS LTD. (IL) 2021-03-30 — — US disclosed
US-20200268709-A1 SMALL MOLECULES AGAINST CANCER BIOKINE THERAPEUTICS LTD. (IL) 2020-08-27 — — US disclosed
US-10646465-B2 Small molecules against cancer BIOKINE THERAPEUTICS LTD. (IL) 2020-05-12 — — US disclosed
US-20190240188-A1 SMALL MOLECULES AGAINST CANCER ALONBIO LTD. (IL) 2019-08-08 — — US disclosed
US-9341605-B2 Chemical profile of detecting bioactive components of quinones, stilbenes, flavones and alkaloids KAOHSIUNG MEDICAL UNIVERSITY (TW) 2016-05-17 — — US disclosed
US-9341605-B2 Chemical profile of detecting bioactive components of quinones, stilbenes, flavones and alkaloids KAOHSIUNG MEDICAL UNIVERSITY (TW) 2016-05-17 — — US disclosed
US-20130000389-A1 CHEMICAL PROFILE OF DETECTING BIOACTIVE COMPONENTS OF QUINONES, STILBENES, FLAVONES AND ALKALOIDS KAOHSIUNG MEDICAL UNIVERSITY (TW) 2013-01-03 — — US disclosed
US-20130000389-A1 CHEMICAL PROFILE OF DETECTING BIOACTIVE COMPONENTS OF QUINONES, STILBENES, FLAVONES AND ALKALOIDS KAOHSIUNG MEDICAL UNIVERSITY (TW) 2013-01-03 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10959979-B2 Small molecules against cancer CCL2, CXCR2, CCL5 USP2 2894/4885HKDC1 1238/4885L3MBTL1 1727/4885
US-10646465-B2 Small molecules against cancer CCL2, CXCR2, CCL5 USP2 2894/4885HKDC1 1238/4885L3MBTL1 1727/4885
US-20200268709-A1 SMALL MOLECULES AGAINST CANCER CCL2, CXCR2, CCL5 USP2 2894/4885HKDC1 1238/4885L3MBTL1 1727/4885
US-20190240188-A1 SMALL MOLECULES AGAINST CANCER CCL2, CXCR2, CCL5 USP2 2894/4885HKDC1 1238/4885L3MBTL1 1727/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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