Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.75 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.75 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.75 |
| ▸ | TUBB4A | P04350 | 4/20 | 0.73 |
| ▸ | TUBB | P07437 | 4/20 | 0.73 |
| ▸ | TUBA3C | P0DPH7 | 4/20 | 0.73 |
| ▸ | TUBA1B | P68363 | 4/20 | 0.73 |
| ▸ | TUBA4A | P68366 | 4/20 | 0.73 |
| ▸ | TUBB4B | P68371 | 4/20 | 0.73 |
| ▸ | TUBB3 | Q13509 | 4/20 | 0.73 |
| ▸ | TUBB2A | Q13885 | 4/20 | 0.73 |
| ▸ | TUBB8 | Q3ZCM7 | 4/20 | 0.73 |
| ▸ | TUBA3E | Q6PEY2 | 4/20 | 0.73 |
| ▸ | TUBA1A | Q71U36 | 4/20 | 0.73 |
| ▸ | TUBA1C | Q9BQE3 | 4/20 | 0.73 |
| ▸ | TUBB6 | Q9BUF5 | 4/20 | 0.73 |
| ▸ | TUBB2B | Q9BVA1 | 4/20 | 0.73 |
| ▸ | TUBB1 | Q9H4B7 | 4/20 | 0.73 |
| ▸ | LMNA | P02545 | 2/20 | 0.73 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14480665 | 0.92 | HDAC6 (0.77) | HDAC6HDAC3HDAC1TUBB4ATUBB | |
| SCHEMBL14480591 | 0.92 | HDAC6 (0.76) | HDAC6HDAC3HDAC1TUBB4ATUBB | |
| SCHEMBL14480648 | 0.89 | TUBB1 (0.70) | HDAC6HDAC3HDAC1TUBB4ATUBB | |
| SCHEMBL23752205 | 0.87 | HDAC6 (0.80) | HDAC6HDAC3HDAC1TUBB4ATUBB | |
| SCHEMBL25662539 | 0.87 | HDAC6 (0.80) | HDAC6HDAC3HDAC1TUBB4ATUBB | |
| SCHEMBL31237187 | 0.87 | HDAC6 (0.86) | HDAC6HDAC3HDAC1TUBB4ATUBB | |
| SCHEMBL14117852 | 0.86 | HDAC6 (0.78) | HDAC6HDAC3HDAC1TUBB4ATUBB | |
| SCHEMBL14556052 | 0.85 | HDAC6 (0.77) | HDAC6HDAC3HDAC1TUBB4ATUBB | |
| SCHEMBL11946951 | 0.85 | HDAC6 (0.77) | HDAC6HDAC3HDAC1TUBB4ATUBB | |
| SCHEMBL30580413 | 0.85 | HDAC6 (0.77) | HDAC6HDAC3HDAC1TUBB4ATUBB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2562156-A2 | COLCHICINE DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, METHOD FOR PREPARING SAID DERIVATIVES, AND PHARMACEUTICAL COMPOSITION COMPRISING SAID DERIVATIVES | The Asan Foundation (KR) | 2013-02-27 | — | — | EP | claimed |
| US-20130011417-A1 | COLCHICINE DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, METHOD FOR PREPARING SAID DERIVATIVES, AND PHARMACEUTICAL COMPOSITION COMPRISING SAID DERIVATIVES | THE ASAN FOUNDATION (KR) | 2013-01-10 | — | — | US | claimed |
| EP-2562156-B1 | COLCHICINE DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, METHOD FOR PREPARING SAID DERIVATIVES, AND PHARMACEUTICAL COMPOSITION COMPRISING SAID DERIVATIVES | ASAN FOUND (KR) | 2018-11-07 | — | — | EP | disclosed |
| US-8927760-B2 | Colchicine derivatives or pharmaceutically acceptable salts thereof, method for preparing said derivatives, and pharmaceutical composition comprising said derivatives | THE ASAN FOUNDATION (KR) | 2015-01-06 | — | — | US | disclosed |
| US-8927760-B2 | Colchicine derivatives or pharmaceutically acceptable salts thereof, method for preparing said derivatives, and pharmaceutical composition comprising said derivatives | THE ASAN FOUNDATION (KR) | 2015-01-06 | — | — | US | disclosed |
| US-8927760-B2 | Colchicine derivatives or pharmaceutically acceptable salts thereof, method for preparing said derivatives, and pharmaceutical composition comprising said derivatives | THE ASAN FOUNDATION (KR) | 2015-01-06 | — | — | US | disclosed |
| EP-2562156-A2 | COLCHICINE DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, METHOD FOR PREPARING SAID DERIVATIVES, AND PHARMACEUTICAL COMPOSITION COMPRISING SAID DERIVATIVES | The Asan Foundation (KR) | 2013-02-27 | — | — | EP | disclosed |
| US-20130011417-A1 | COLCHICINE DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, METHOD FOR PREPARING SAID DERIVATIVES, AND PHARMACEUTICAL COMPOSITION COMPRISING SAID DERIVATIVES | THE ASAN FOUNDATION (KR) | 2013-01-10 | — | — | US | disclosed |
| US-20130011417-A1 | COLCHICINE DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, METHOD FOR PREPARING SAID DERIVATIVES, AND PHARMACEUTICAL COMPOSITION COMPRISING SAID DERIVATIVES | THE ASAN FOUNDATION (KR) | 2013-01-10 | — | — | US | disclosed |
| US-20130011417-A1 | COLCHICINE DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, METHOD FOR PREPARING SAID DERIVATIVES, AND PHARMACEUTICAL COMPOSITION COMPRISING SAID DERIVATIVES | THE ASAN FOUNDATION (KR) | 2013-01-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130011417-A1 | COLCHICINE DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, METHOD FOR PREPARING SAID DERIVATIVES, AND PHARMACEUTICAL COMPOSITION COMPRISING SAID DERIVATIVES | MYD88, IL5, NOD1 | HDAC6 736/4885HDAC3 3821/4885HDAC1 2810/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.