NOD1 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL15474	0.75	13/20
SCHEMBL15475	0.75	13/20
SCHEMBL133586	0.61	13/20
SCHEMBL138443	0.56	13/20
SCHEMBL131586	0.77	12/20
SCHEMBL132483	0.77	12/20
SCHEMBL29326	0.75	11/20
SCHEMBL93869	0.75	11/20
SCHEMBL91077	0.64	11/20
SCHEMBL137710	0.59	11/20
SCHEMBL155008	0.64	10/20
SCHEMBL38281	0.60	10/20
SCHEMBL71062	0.46	10/20
SCHEMBL55273	0.82	9/20
SCHEMBL55274	0.82	9/20
SCHEMBL170159	0.82	9/20
SCHEMBL170160	0.82	9/20
SCHEMBL154648	0.79	9/20
SCHEMBL159307	0.79	9/20
SCHEMBL72619	0.65	9/20

Clinical trials — most relevant to NOD1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
The Possible Efficacy and Protective Effect of Empagliflozin in Rheumatoid Arthritis Patients Treated with Methotrexate	PHASE4	NOT_YET_RECRUITING
Colchicine for Symptom and Inflammation in Knee Osteoarthritis	PHASE2/PHASE3	COMPLETED
CMP-MYTHiC Trial and Registry - CardioMyoPathy With MYocarditis THerapy With Colchicine	PHASE3	RECRUITING
Colchicine to Suppress Inflammation and Improve Insulin Resistance in Adults and Adolescents With Obesity	PHASE2	COMPLETED
The Effects of GLA on Human Volunteers	PHASE1	COMPLETED
Clinical Effects of New Approach on Patients With Non-alcoholic Steatohepatitis	EARLY_PHASE1	COMPLETED
Inflammasomes in Cell Death in FTMH, ERM, and RRD	nan	COMPLETED
Probiotics and Systemic Inflammation in Patients With Metabolic Syndrome and High Cardiovascular Risk	nan	WITHDRAWN
Effect of Periodontal Treatment on Inflammasome Proteins in Periodontal Diseases	nan	UNKNOWN
Evaluation of Nucleotide-Binding Oligomerization Domain-Containing Protein (NOD) 1 and NOD 2	nan	NOT_YET_RECRUITING
Nucleotide Protein -3 in Epileptic Children	nan	UNKNOWN
Role of Type 2 Diabetes in Potentiating the Inflammatory Response Post Extracorporeal Circulation After Cardiac Surgery	nan	WITHDRAWN
Characterization of Non-canonical Way in Inflammasome Monocytes of Patients With Severe Sepsis	nan	COMPLETED
Potential Role of Inflammasome NLRP3 And IL-1B Gene Expression in COVID-19 Patients: Impact of Ferretin and D -Dimer.	nan	UNKNOWN
New Signaling Pathway Targeting Systemic Lupus Erythematosus	nan	UNKNOWN
Omega-3 to Reduce Diabetes Risk in Subjects With High Number of Particles That Carry Bad Cholesterol in the Blood	nan	COMPLETED
Effect of Low Dose of Colchicine on Platelet Reactivity	nan	COMPLETED
The Mechanisms and Significances of Synergistic Effects of Mycophenolic Acid and LPS on IL-1β Secretion by Mononuclear	nan	UNKNOWN
(NOD)-Like Receptors CARD Domain-Containing 4 Levels in Individuals With Periodontitis	nan	UNKNOWN
Evaluation of Inflammasome Gene Polymorphisms in Periodontitis Patients	nan	UNKNOWN
TRPM2 Gene Polymorphism, NLRP3 Inflammasome Expression in Vitiligo Patients	nan	ACTIVE_NOT_RECRUITING
Gluten-related Disorders in Familial Mediterranean Fever Patients	nan	COMPLETED
Evaluation of Serum Gasdermin D Level As a Potential Biomarker of Disease Activity in Vitiligo Patients	nan	UNKNOWN
Effect of Non-chirurgical Periodontal Treatment on the Immune System From a Gender Perspective	nan	COMPLETED
Role NLRP3 Inflammasome in Weight Loss Following Sleeve Gastrectomy in Morbidly Obese Patients	nan	UNKNOWN
Suppression of Postprandial Monocyte Activation by Blueberries or Docosahexaenoic Acid in Humans	nan	COMPLETED
The Role of Toll-like Receptor-4 in Periodontitis Patients With End-stage Renal Disease in a Sample of Egyptian Population	nan	RECRUITING
Effect of Natural Senolytic Agents & NLRP3 Inhibitors on Osteoarthritis	nan	SUSPENDED
Exploration of the Activity of DNA Located Outside of Cellular Nucleus to Amplify Inflammation in Inflammatory Bowel Disease in Children Through Biological Pathway Cyclic GMP-AMP Synthase (cGAS) - Stimulator of Interferon Genes (STING)	nan	COMPLETED
RNA Cloning and Visualization in Human Atherosclerosis	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a NOD1 binder may also engage these)

Protein	Name	Similarity
Q8BHB0	—	1.000	Q8BHB0 →
Q8K3Z0	—	0.994	Q8K3Z0 →
Q53B88	—	0.993	Q53B88 →
Q6E804	—	0.991	Q6E804 →
G1T469	—	0.990	G1T469 →
NOD2	Nucleotide-binding oligomerization domain-containing protein 2	0.990	landscape →
Q53B87	—	0.989	Q53B87 →
Q3TL44	—	0.983	Q3TL44 →
Q5FVQ8	—	0.983	Q5FVQ8 →
Q86UT6	—	0.983	Q86UT6 →
Q9NPP4	—	0.979	Q9NPP4 →
Q9NX02	—	0.975	Q9NX02 →
F1M649	—	0.975	F1M649 →
Q7TNH6	—	0.974	Q7TNH6 →
O35732	—	0.973	O35732 →
C3VPR6	—	0.973	C3VPR6 →
Q8WX94	—	0.973	Q8WX94 →
F1MHT9	—	0.973	F1MHT9 →
P0CI65	—	0.972	P0CI65 →
Q7RTR0	—	0.971	Q7RTR0 →
A1IGU4	—	0.970	A1IGU4 →
Q2LKU9	—	0.970	Q2LKU9 →
Q3UP24	—	0.970	Q3UP24 →
Q96MN2	—	0.969	Q96MN2 →
Q9BXL6	—	0.969	Q9BXL6 →
P59046	—	0.969	P59046 →
Q6R653	—	0.969	Q6R653 →
Q8NE28	—	0.968	Q8NE28 →
Q7Z494	—	0.968	Q7Z494 →
Q288C4	—	0.968	Q288C4 →