Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 2/20 | 0.65 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.65 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.65 |
| ▸ | QPCT | Q16769 | 2/20 | 0.49 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.45 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.45 |
| ▸ | PRKDC | P78527 | 4/20 | 0.45 |
| ▸ | IP6K1 | Q92551 | 3/20 | 0.45 |
| ▸ | IP6K3 | Q96PC2 | 2/20 | 0.45 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.44 |
| ▸ | KIF11 | P52732 | 1/20 | 0.42 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.41 |
| ▸ | XDH | P47989 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8871223 | 0.90 | PIK3CD (0.60) | PIK3CDPIK3CAPIK3CBQPCTPDE3B | |
| SCHEMBL18108512 | 0.79 | PIK3CA (0.63) | PIK3CDPIK3CAPIK3CBQPCTPDE3B | |
| SCHEMBL2426171 | 0.79 | PIK3CD (1.00) | PIK3CDPIK3CAPIK3CBQPCTPRKDC | |
| SCHEMBL30823308 | 0.79 | PIK3CD (1.00) | PIK3CDPIK3CAPIK3CBQPCTPRKDC | |
| SCHEMBL23122757 | 0.78 | PIK3CD (0.66) | PIK3CDPIK3CAPIK3CBQPCTPDE3B | |
| SCHEMBL29745276 | 0.78 | PIK3CD (0.66) | PIK3CDPIK3CAPIK3CBQPCTPDE3B | |
| SCHEMBL28826859 | 0.77 | PIK3CD (0.53) | PIK3CDPIK3CAPIK3CBPDE3BPDE3A | |
| SCHEMBL8976318 | 0.77 | IP6K1 (0.61) | PIK3CDPIK3CAPIK3CBIP6K1IP6K3 | |
| SCHEMBL8871230 | 0.76 | PIK3CD (0.80) | PIK3CDPIK3CAPIK3CBQPCTIP6K1 | |
| SCHEMBL8871355 | 0.75 | IP6K1 (0.62) | PIK3CDPIK3CAPIK3CBPDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2547664-B1 | MORPHOLINYLQUINAZOLINES | MERCK PATENT GMBH (DE) | 2016-05-04 | — | — | EP | disclosed |
| US-9126952-B2 | Morpholinylquinazolines | MERCK PATENT GMBH (DE) | 2015-09-08 | — | — | US | disclosed |
| US-20130012489-A1 | Morpholinylquinazolines | MERCK PATENT GMBH (DE) | 2013-01-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130012489-A1 | Morpholinylquinazolines | LATS2, TNK2, SKP1 | PIK3CD 1763/4885PIK3CA 643/4885PIK3CB 2472/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.