Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 1/20 | 0.60 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.60 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.60 |
| ▸ | QPCT | Q16769 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.47 |
| ▸ | MAPT | P10636 | 6/20 | 0.47 |
| ▸ | HPGD | P15428 | 5/20 | 0.47 |
| ▸ | CASP1 | P29466 | 4/20 | 0.47 |
| ▸ | CASP7 | P55210 | 4/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | IP6K1 | Q92551 | 2/20 | 0.47 |
| ▸ | IP6K3 | Q96PC2 | 1/20 | 0.47 |
| ▸ | KIF11 | P52732 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 6/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.46 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14481463 | 0.90 | PIK3CD (0.65) | PIK3CDPIK3CAPIK3CBQPCTKDM4E | |
| SCHEMBL8976318 | 0.87 | IP6K1 (0.61) | PIK3CDPIK3CAPIK3CBALDH1A1MAPT | |
| SCHEMBL8871355 | 0.86 | IP6K1 (0.62) | PIK3CDPIK3CAPIK3CBALDH1A1MAPT | |
| SCHEMBL23122757 | 0.80 | PIK3CD (0.66) | PIK3CDPIK3CAPIK3CBQPCTKDM4E | |
| SCHEMBL29745276 | 0.80 | PIK3CD (0.66) | PIK3CDPIK3CAPIK3CBQPCTKDM4E | |
| SCHEMBL18108512 | 0.78 | PIK3CA (0.63) | PIK3CDPIK3CAPIK3CBQPCTKDM4E | |
| SCHEMBL8871230 | 0.78 | PIK3CD (0.80) | PIK3CDPIK3CAPIK3CBQPCTIP6K1 | |
| SCHEMBL30823308 | 0.75 | PIK3CD (1.00) | PIK3CDPIK3CAPIK3CBQPCTALDH1A1 | |
| SCHEMBL2426171 | 0.75 | PIK3CD (1.00) | PIK3CDPIK3CAPIK3CBQPCTALDH1A1 | |
| SCHEMBL30689022 | 0.72 | ALDH1A1 (0.62) | PIK3CDPIK3CAPIK3CBKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2547664-B1 | MORPHOLINYLQUINAZOLINES | MERCK PATENT GMBH (DE) | 2016-05-04 | — | — | EP | disclosed |
| US-5616582-A | Use as anticancer agents; e.g. gefitinib | ZENECA LIMITED (GB) | 1997-04-01 | — | — | US | disclosed |
| EP-0566226-B1 | Quinazoline derivatives | ZENECA LTD (GB) | 1995-11-08 | — | — | EP | disclosed |
| US-5457105-A | anticancer use; e.g. 4-(3'-chloro-4'-fluoroanilino)-6,7-dimethoxyquinazoline (gefitinib) | ZENECA LIMITED (GB) | 1995-10-10 | — | — | US | disclosed |
| EP-0566226-A1 | Quinazoline derivatives | ZENECA LIMITED (GB) | 1993-10-20 | — | — | EP | disclosed |