Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | CA1 | P00915 | 2/20 | 0.44 |
| ▸ | CA2 | P00918 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.43 |
| ▸ | NOS2 | P35228 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1448157 | 1.00 | TP53 (0.44) | TP53CA1CA2TSHRALDH1A1 | |
| SCHEMBL1448154 | 1.00 | TP53 (0.44) | TP53CA1CA2TSHRALDH1A1 | |
| SCHEMBL5797993 | 0.78 | NPSR1 (0.53) | TP53KDM4ELMNAHPGDNOS2 | |
| SCHEMBL1449440 | 0.76 | TP53 (0.53) | TP53CA1CA2TSHRALDH1A1 | |
| SCHEMBL1449437 | 0.76 | TP53 (0.53) | TP53CA1CA2TSHRALDH1A1 | |
| SCHEMBL1449441 | 0.76 | TP53 (0.53) | TP53CA1CA2TSHRALDH1A1 | |
| Oletimol SCHEMBL1449613 | 0.73 | KMT2A (0.57) | CA1CA2TSHRALDH1A1KDM4E | |
| Oletimol SCHEMBL1449615 | 0.73 | KMT2A (0.57) | CA1CA2TSHRALDH1A1KDM4E | |
| Oletimol SCHEMBL1449610 | 0.73 | KMT2A (0.57) | CA1CA2TSHRALDH1A1KDM4E | |
| SCHEMBL28097048 | 0.71 | TDP1 (0.56) | CA1CA2ALDH1A1LMNATAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2373758-B1 | PHOTOCHROMIC OPTICAL ARTICLES PREPARED WITH REVERSIBLE THERMOCHROMIC MATERIALS | TRANSITIONS OPTICAL INC (US) | 2017-05-10 | — | — | EP | disclosed |
| US-8547625-B2 | Photochromic optical articles prepared with reversible thermochromic materials | TRANSITIONS OPTICAL, INC. (US) | 2013-10-01 | — | — | US | disclosed |
| EP-2373758-A1 | PHOTOCHROMIC OPTICAL ARTICLES PREPARED WITH REVERSIBLE THERMOCHROMIC MATERIALS | TRANSITIONS OPTICAL, INC. (US) | 2011-10-12 | — | — | EP | disclosed |
| US-7911676-B2 | Photochromic optical articles prepared with reversible thermochromic materials | TRANSITIONS OPTICAL, INC. (US) | 2011-03-22 | — | — | US | disclosed |
| US-20110051223-A1 | PHOTOCHROMIC OPTICAL ARTICLES PREPARED WITH REVERSIBLE THERMOCHROMIC MATERIALS | TRANSITIONS OPTICAL, INC. (FL) | 2011-03-03 | — | — | US | disclosed |
| WO-2010074969-A1 | PHOTOCHROMIC OPTICAL ARTICLES PREPARED WITH REVERSIBLE THERMOCHROMIC MATERIALS | TRANSITIONS OPTICAL, INC. (US) | 2010-07-01 | — | — | WO | disclosed |
| US-20100149620-A1 | PHOTOCHROMIC OPTICAL ARTICLES PREPARED WITH REVERSIBLE THERMOCHROMIC MATERIALS | TRANSITIONS OPTICAL, INC. (US) | 2010-06-17 | — | — | US | disclosed |