Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.61 |
| ▸ | RAB9A | P51151 | 7/20 | 0.61 |
| ▸ | NAMPT | P43490 | 2/20 | 0.52 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.49 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.49 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14484167 | 0.91 | RAB9A (0.74) | NPC1RAB9ANAMPTSMN1; SMN2MAPT | |
| SCHEMBL31720872 | 0.85 | NAMPT (0.58) | NPC1RAB9ANAMPTSMN1; SMN2MAPT | |
| SCHEMBL26603124 | 0.85 | NAMPT (0.58) | NPC1RAB9ANAMPTSMN1; SMN2MAPT | |
| SCHEMBL26603141 | 0.81 | NPC1 (0.53) | NPC1RAB9ANAMPTSMN1; SMN2MAPT | |
| SCHEMBL31720918 | 0.81 | NPC1 (0.53) | NPC1RAB9ANAMPTSMN1; SMN2MAPT | |
| SCHEMBL31720899 | 0.79 | NAMPT (0.57) | NPC1RAB9ANAMPTSMN1; SMN2MAPT | |
| SCHEMBL26603159 | 0.79 | NAMPT (0.57) | NPC1RAB9ANAMPTSMN1; SMN2MAPT | |
| SCHEMBL13836668 | 0.79 | NPC1 (0.71) | NPC1RAB9ASMN1; SMN2MAPTTP53 | |
| SCHEMBL31720953 | 0.79 | NPC1 (0.53) | NPC1RAB9ANAMPTSMN1; SMN2MAPT | |
| SCHEMBL26603119 | 0.79 | NPC1 (0.53) | NPC1RAB9ANAMPTSMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7230020-B2 | 11β-hydroxysteroid dehydrogenase inhibitors | STERIX LIMITED (GB) | 2007-06-12 | — | — | US | disclosed |
| US-7230020-B2 | 11β-hydroxysteroid dehydrogenase inhibitors | STERIX LIMITED (GB) | 2007-06-12 | — | — | US | disclosed |