Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 9/20 | 0.61 |
| ▸ | PDE4A | P27815 | 7/20 | 0.61 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.61 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.61 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.61 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.61 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MPI | P34949 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | MIF | P14174 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5203405 | 0.90 | PDE4B (0.63) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL3072114 | 0.80 | PDE4B (0.52) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL3054495 | 0.80 | PDE4B (0.52) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL3069582 | 0.78 | PDE4A (0.55) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL6935016 | 0.76 | PDE4B (1.00) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL23768672 | 0.74 | MEN1 (0.43) | KDM4EALDH1A1MAPTTDP1HSD17B10 | |
| SCHEMBL9869903 | 0.72 | PDE4A (0.57) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL28303332 | 0.71 | PDE4B (0.56) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL3775165 | 0.71 | PDE4B (0.76) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL14484314 | 0.71 | PDE4B (0.60) | PDE4BPDE4APDE4CPDE4DPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170368030-A1 | Dihydropyrazoles | MERCK PATENT GMBH (DE) | 2017-12-28 | — | — | US | disclosed |
| US-20170368030-A1 | Dihydropyrazoles | MERCK PATENT GMBH (DE) | 2017-12-28 | — | — | US | disclosed |
| US-9775830-B2 | Dihydropyrazoles | MERCK PATENT GMBH (DE) | 2017-10-03 | — | — | US | disclosed |
| US-9775830-B2 | Dihydropyrazoles | MERCK PATENT GMBH (DE) | 2017-10-03 | — | — | US | disclosed |
| US-9775830-B2 | Dihydropyrazoles | MERCK PATENT GMBH (DE) | 2017-10-03 | — | — | US | disclosed |
| US-20170071910-A1 | Dihydropyrazoles | MERCK PATENT GMBH (DE) | 2017-03-16 | — | — | US | disclosed |
| US-20170071910-A1 | Dihydropyrazoles | MERCK PATENT GMBH (DE) | 2017-03-16 | — | — | US | disclosed |
| US-20170071910-A1 | Dihydropyrazoles | MERCK PATENT GMBH (DE) | 2017-03-16 | — | — | US | disclosed |
| US-9517227-B2 | Dihydropyrazoles | MERCK PATENT GMBH (DE) | 2016-12-13 | — | — | US | disclosed |
| US-9517227-B2 | Dihydropyrazoles | MERCK PATENT GMBH (DE) | 2016-12-13 | — | — | US | disclosed |
| US-8791114-B2 | Dihydropyrazoles | MERCK PATENT GMBH (DE) | 2014-07-29 | — | — | US | disclosed |
| US-8791114-B2 | Dihydropyrazoles | MERCK PATENT GMBH (DE) | 2014-07-29 | — | — | US | disclosed |
| US-8791114-B2 | Dihydropyrazoles | MERCK PATENT GMBH (DE) | 2014-07-29 | — | — | US | disclosed |
| CN-103827091-A | Dihydropyrazoles, pharmaceutical compositions thereof and their use for the treatment of fertility disorders | MERCK PATENT GMBH | 2014-05-28 | — | — | CN | disclosed |
| EP-2726463-A2 | DIHYDROPYRAZOLES | Merck Patent GmbH (DE) | 2014-05-07 | — | — | EP | disclosed |
| US-20130172351-A1 | Dihydropyrazoles | MERCK PATENT GMBH (DE) | 2013-07-04 | — | — | US | disclosed |
| US-20130172351-A1 | Dihydropyrazoles | MERCK PATENT GMBH (DE) | 2013-07-04 | — | — | US | disclosed |
| US-20130172351-A1 | Dihydropyrazoles | MERCK PATENT GMBH (DE) | 2013-07-04 | — | — | US | disclosed |
| WO-2013006308-A2 | DIHYDROPYRAZOLES | MERCK PATENT GMBH (DE) | 2013-01-10 | — | — | WO | disclosed |
| WO-2013006308-A2 | DIHYDROPYRAZOLES | MERCK PATENT GMBH (DE) | 2013-01-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170368030-A1 | Dihydropyrazoles | FSHR, GNRHR, LHCGR | PDE4B 367/4885PDE4A 371/4885PDE4C 721/4885 |
| US-20130172351-A1 | Dihydropyrazoles | FSHR, GNRHR, LHCGR | PDE4B 367/4885PDE4A 371/4885PDE4C 721/4885 |
| US-20170071910-A1 | Dihydropyrazoles | FSHR, GNRHR, LHCGR | PDE4B 367/4885PDE4A 371/4885PDE4C 721/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.