Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 2/20 | 0.72 |
| ▸ | MAPT | P10636 | 10/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.66 |
| ▸ | GAA | P10253 | 3/20 | 0.66 |
| ▸ | RAB9A | P51151 | 6/20 | 0.63 |
| ▸ | POLB | P06746 | 4/20 | 0.63 |
| ▸ | NPC1 | O15118 | 3/20 | 0.63 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.63 |
| ▸ | LMNA | P02545 | 5/20 | 0.58 |
| ▸ | HPGD | P15428 | 3/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.58 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 4/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12742913 | 1.00 | RECQL (0.72) | RECQLMAPTALDH1A1SMN1; SMN2GAA | |
| SCHEMBL1449217 | 0.86 | RECQL (0.66) | RECQLMAPTALDH1A1SMN1; SMN2GAA | |
| SCHEMBL14063274 | 0.86 | RECQL (0.66) | RECQLMAPTALDH1A1SMN1; SMN2GAA | |
| SCHEMBL12742903 | 0.86 | RECQL (0.66) | RECQLMAPTALDH1A1SMN1; SMN2GAA | |
| SCHEMBL425338 | 0.84 | RECQL (1.00) | RECQLMAPTALDH1A1SMN1; SMN2GAA | |
| SCHEMBL446006 | 0.84 | RECQL (1.00) | RECQLMAPTALDH1A1SMN1; SMN2GAA | |
| SCHEMBL29176317 | 0.84 | RECQL (1.00) | RECQLMAPTALDH1A1SMN1; SMN2GAA | |
| SCHEMBL23251385 | 0.82 | MAPT (0.81) | RECQLMAPTALDH1A1SMN1; SMN2GAA | |
| SCHEMBL12275056 | 0.81 | RECQL (0.79) | RECQLMAPTALDH1A1SMN1; SMN2GAA | |
| SCHEMBL12275054 | 0.81 | RECQL (0.79) | RECQLMAPTALDH1A1SMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7910744-B2 | Pyrazole and Pyrimidine groups are introduced on aromatic phosphine; (3-bromophenyl)methyl ketone and ethylene glycol cyclize to [3-(2-methyl-1,3-dioxolane-2-yl)phenyl]diphenylphosphane; adding hydrazine monohydrate, then oxidizing with hydrogen peroxide; [3-(3-Pyrazolyl)phenyl]diphenylphosphane oxide | ZYLUM BETEILIGUNGSGESELLSCHAFT MBH & CO. PATENT II KG (DE) | 2011-03-22 | — | — | US | disclosed |