SCHEMBL425338

SCHEMBL425338

CN(C)/C=C/C(=O)c1ccccc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
RECQL P46063 2/20 1.00
ALDH1A1 P00352 10/20 0.72
RAB9A P51151 6/20 0.72
SMN1; SMN2 Q16637 3/20 0.72
POLB P06746 3/20 0.72
NPC1 O15118 3/20 0.72
HSP90AA1 P07900 1/20 0.72
MAPT P10636 9/20 0.70
GAA P10253 3/20 0.70
HTT P42858 4/20 0.67
LMNA P02545 4/20 0.67
HPGD P15428 3/20 0.67
CYP1A2 P05177 2/20 0.67
CYP2C19 P33261 2/20 0.67
ALOX12 P18054 1/20 0.67
KMT2A Q03164 2/20 0.59
MEN1 O00255 1/20 0.57
TDP1 Q9NUW8 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL446006 1.00 RECQL (1.00) RECQLALDH1A1RAB9ASMN1; SMN2POLB
SCHEMBL29176317 1.00 RECQL (1.00) RECQLALDH1A1RAB9ASMN1; SMN2POLB
SCHEMBL23251385 0.89 MAPT (0.81) RECQLALDH1A1RAB9ASMN1; SMN2POLB
SCHEMBL12275054 0.89 RECQL (0.79) RECQLALDH1A1RAB9ASMN1; SMN2POLB
SCHEMBL12275056 0.89 RECQL (0.79) RECQLALDH1A1RAB9ASMN1; SMN2POLB
SCHEMBL4894896 0.86 RECQL (0.75) RECQLALDH1A1RAB9ASMN1; SMN2POLB
SCHEMBL4894903 0.86 RECQL (0.75) RECQLALDH1A1RAB9ASMN1; SMN2POLB
SCHEMBL5946453 0.86 MAPT (0.77) RECQLALDH1A1RAB9ASMN1; SMN2POLB
SCHEMBL1448532 0.84 RECQL (0.72) RECQLALDH1A1RAB9ASMN1; SMN2POLB
SCHEMBL12742913 0.84 RECQL (0.72) RECQLALDH1A1RAB9ASMN1; SMN2POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 269 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-122080001-A Perfluoroalkyl substituted pyrimido [1,2-b ] indazole ketone compound and preparation method thereof 2026-05-26 CN claimed
CN-119019332-A 1, 5-Disubstituted-4-bromopyrazole compound and preparation method and application thereof 赣南师范大学 2024-11-26 CN claimed
CN-118834161-A Preparation method of 3-sulfonyl-5-acetyl-1, 4 dihydropyridine compound 西北工业大学 2024-10-25 CN claimed
CN-116396145-A Preparation method of 9-phenanthrene phenol compound 西北工业大学 2023-07-07 CN claimed
CN-114656430-A 3, 3-difluoromethylene nucleoside compound and preparation method and application thereof 南京工业大学 2022-06-24 CN claimed
CN-107915650-B Method for selectively preparing α -acyloxy or β -acyloxy products of enaminone compounds 南京工业大学 2020-05-26 CN claimed
CN-107522606-B Synthetic method of 2-methyl-4-carbonyl-2, 4-diphenylbutanal 南京工业大学 2020-04-14 CN claimed
CN-107739368-B N-substituted-5- ((4-substituted pyrimidine-2-yl) amino) indole derivatives, and preparation method and application thereof 厦门大学 2020-02-14 CN claimed
CN-107915650-A Method for selectively preparing α -acyloxy or β -acyloxy products of enaminone compounds 南京工业大学 2018-04-17 CN claimed
EP-1000012-A1 PROCESS FOR CONVERTING PROPARGYLIC AMINE-N-OXIDES TO ENAMINONES AMERICAN HOME PRODUCTS CORPORATION (US) 2000-05-17 EP claimed
US-5932745-A HYDROXYLIC SOLVENT AMERICAN HOME PRODUCTS CORPORATION (US) 1999-08-03 US claimed
WO-1999006351-A1 PROCESS FOR CONVERTING PROPARGYLIC AMINE-N-OXIDES TO ENAMINONES AMERICAN HOME PRODUCTS CORPORATION (US) 1999-02-11 WO claimed
JP-3141251-A None JP disclosed
JP-3141252-A None JP disclosed
CN-122080001-A Perfluoroalkyl substituted pyrimido [1,2-b ] indazole ketone compound and preparation method thereof 2026-05-26 CN disclosed
EP-3994125-B1 MODULATORS OF HSD17B13 AND METHODS OF USE THEREOF REGENERON PHARMA (US) 2025-12-24 EP disclosed
EP-0425247-A2 5-Substituted-2,4-diphenylpyrimidine derivatives, their production and herbicidal use SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1991-05-02 EP disclosed
US-4971979-A Antiinflammatory agents RHONE-POULENC SANTE (FR) 1990-11-20 US disclosed
EP-0166697-B1 AROYL SUBSTITUTED DIHYDRO-1,4-THIAZINES CIBA-GEIGY AG (CH) 1990-05-09 EP disclosed
US-4886835-A ANTIINFLAMMATORY AGENTS RHONE-POULENC SANTE (FR) 1989-12-12 US disclosed