Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 16/20 | 0.64 |
| ▸ | CDK1 | P06493 | 8/20 | 0.63 |
| ▸ | IKBKB | O14920 | 1/20 | 0.51 |
| ▸ | CHUK | O15111 | 1/20 | 0.51 |
| ▸ | IKBKG | Q9Y6K9 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1448906 | 0.87 | CDK2 (0.65) | CDK2CDK1IKBKBCHUKIKBKG | |
| SCHEMBL1448567 | 0.87 | CDK2 (0.65) | CDK2CDK1IKBKBCHUKIKBKG | |
| SCHEMBL1447265 | 0.86 | CDK2 (0.69) | CDK2CDK1KCNH2 | |
| SCHEMBL1447839 | 0.86 | CDK2 (0.67) | CDK2CDK1IKBKBCHUKIKBKG | |
| SCHEMBL1448088 | 0.84 | CDK2 (0.66) | CDK2CDK1IKBKBCHUKIKBKG | |
| SCHEMBL1447182 | 0.84 | CDK2 (0.83) | CDK2CDK1KCNH2 | |
| SCHEMBL1447236 | 0.84 | CDK2 (0.83) | CDK2CDK1KCNH2 | |
| SCHEMBL1447616 | 0.84 | CDK2 (0.83) | CDK2CDK1KCNH2 | |
| SCHEMBL1448064 | 0.83 | CDK2 (0.61) | CDK2CDK1IKBKBCHUKIKBKG | |
| SCHEMBL1447670 | 0.83 | CDK2 (0.61) | CDK2CDK1IKBKBCHUKIKBKG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2301928-A1 | Imidazolyl-pyrimidine compounds for use in the treatment of proliferative disorders | AstraZeneca AB (SE) | 2011-03-30 | — | — | EP | disclosed |