Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 16/20 | 0.66 |
| ▸ | CDK1 | P06493 | 7/20 | 0.65 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.47 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.45 |
| ▸ | SYK | P43405 | 1/20 | 0.45 |
| ▸ | IKBKB | O14920 | 1/20 | 0.44 |
| ▸ | CHUK | O15111 | 1/20 | 0.44 |
| ▸ | IKBKG | Q9Y6K9 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1447265 | 0.98 | CDK2 (0.69) | CDK2CDK1KCNH2TBK1SYK | |
| SCHEMBL1448559 | 0.94 | CDK2 (0.73) | CDK2CDK1KCNH2SYK | |
| SCHEMBL1447113 | 0.86 | CDK2 (0.74) | CDK2CDK1KCNH2 | |
| SCHEMBL1447567 | 0.85 | CDK2 (0.72) | CDK2CDK1KCNH2 | |
| SCHEMBL1447628 | 0.85 | CDK2 (0.69) | CDK2CDK1KCNH2SYKIKBKB | |
| SCHEMBL1447174 | 0.85 | CDK2 (0.61) | CDK2CDK1KCNH2SYKIKBKB | |
| SCHEMBL1448568 | 0.84 | CDK2 (0.64) | CDK2CDK1KCNH2IKBKBCHUK | |
| SCHEMBL1447563 | 0.84 | CDK2 (0.72) | CDK2CDK1KCNH2TBK1SYK | |
| SCHEMBL1447698 | 0.83 | CDK2 (0.93) | CDK2CDK1KCNH2 | |
| SCHEMBL1447876 | 0.82 | CDK2 (0.73) | CDK2CDK1KCNH2SYKIKBKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2301928-A1 | Imidazolyl-pyrimidine compounds for use in the treatment of proliferative disorders | AstraZeneca AB (SE) | 2011-03-30 | — | — | EP | disclosed |