Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 3/20 | 0.67 |
| ▸ | F2 | P00734 | 2/20 | 0.51 |
| ▸ | PROC | P04070 | 1/20 | 0.51 |
| ▸ | MMP1 | P03956 | 5/20 | 0.51 |
| ▸ | FCER2 | P06734 | 3/20 | 0.51 |
| ▸ | MMP2 | P08253 | 4/20 | 0.45 |
| ▸ | LTA4H | P09960 | 1/20 | 0.45 |
| ▸ | BACE1 | P56817 | 1/20 | 0.45 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.45 |
| ▸ | CPB2 | Q96IY4 | 2/20 | 0.44 |
| ▸ | REN | P00797 | 1/20 | 0.43 |
| ▸ | F2RL1 | P55085 | 2/20 | 0.42 |
| ▸ | MMP3 | P08254 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21669886 | 0.89 | KLKB1 (0.83) | KLKB1F2PROCMMP1FCER2 | |
| SCHEMBL14485442 | 0.89 | KLKB1 (0.83) | KLKB1F2PROCMMP1FCER2 | |
| Trifluoroacetic Acid SCHEMBL15900948 | 0.85 | KLKB1 (0.77) | KLKB1F2PROCMMP1FCER2 | |
| SCHEMBL14485877 | 0.83 | KLKB1 (0.82) | KLKB1F2PROCMMP1FCER2 | |
| SCHEMBL14485873 | 0.83 | KLKB1 (0.82) | KLKB1F2PROCMMP1FCER2 | |
| SCHEMBL14485703 | 0.81 | KLKB1 (0.62) | KLKB1F2PROCMMP1FCER2 | |
| SCHEMBL14485630 | 0.80 | KLKB1 (1.00) | KLKB1MMP1FCER2 | |
| SCHEMBL14486255 | 0.79 | KLKB1 (0.76) | KLKB1MMP1FCER2MMP2 | |
| SCHEMBL15901162 | 0.79 | KLKB1 (0.76) | KLKB1MMP1FCER2MMP2 | |
| SCHEMBL14485616 | 0.78 | KLKB1 (0.78) | KLKB1MMP1FCER2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2729443-A1 | BENZYLAMINE DERIVATIVES AS INHIBITORS OF PLASMA KALLIKREIN | Kalvista Pharmaceuticals Limited (GB) | 2014-05-14 | — | — | EP | disclosed |
| WO-2013005045-A1 | BENZYLAMINE DERIVATIVES AS INHIBITORS OF PLASMA KALLIKREIN | KALVISTA PHARMACEUTICALS LIMITED (GB) | 2013-01-10 | — | — | WO | disclosed |