Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCH | P24723 | 20/20 | 0.79 |
| ▸ | PRKCQ | Q04759 | 20/20 | 0.79 |
| ▸ | PRKCD | Q05655 | 20/20 | 0.79 |
| ▸ | PRKCA | P17252 | 19/20 | 0.79 |
| ▸ | PRKCB | P05771 | 18/20 | 0.79 |
| ▸ | PRKCE | Q02156 | 17/20 | 0.79 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.72 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.72 |
| ▸ | PIM1 | P11309 | 2/20 | 0.72 |
| ▸ | MARK3 | P27448 | 2/20 | 0.72 |
| ▸ | LTK | P29376 | 2/20 | 0.72 |
| ▸ | GRK5 | P34947 | 2/20 | 0.72 |
| ▸ | KDR | P35968 | 2/20 | 0.72 |
| ▸ | GSK3A | P49840 | 2/20 | 0.72 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.72 |
| ▸ | JAK3 | P52333 | 2/20 | 0.72 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.72 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.72 |
| ▸ | MST1R | Q04912 | 2/20 | 0.72 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14555068 | 0.91 | PRKCH (0.74) | PRKCHPRKCQPRKCDPRKCAPRKCB | |
| SCHEMBL14555069 | 0.88 | PRKCH (0.69) | PRKCHPRKCQPRKCDPRKCAPRKCB | |
| SCHEMBL14555064 | 0.87 | PRKCH (0.70) | PRKCHPRKCQPRKCDPRKCAPRKCB | |
| SCHEMBL14555061 | 0.85 | PRKCH (0.65) | PRKCHPRKCQPRKCDPRKCAPRKCB | |
| Sotrastaurin SCHEMBL3846239 | 0.84 | PRKCH (0.93) | PRKCHPRKCQPRKCDPRKCAPRKCB | |
| Sotrastaurin SCHEMBL29412439 | 0.84 | PRKCH (0.93) | PRKCHPRKCQPRKCDPRKCAPRKCB | |
| Sotrastaurin SCHEMBL29526075 | 0.84 | PRKCH (1.00) | PRKCHPRKCQPRKCDPRKCAPRKCB | |
| Sotrastaurin SCHEMBL29364923 | 0.84 | PRKCH (1.00) | PRKCHPRKCQPRKCDPRKCAPRKCB | |
| Sotrastaurin SCHEMBL2500835 | 0.84 | PRKCH (1.00) | PRKCHPRKCQPRKCDPRKCAPRKCB | |
| SCHEMBL14555065 | 0.82 | PRKCH (0.63) | PRKCHPRKCQPRKCDPRKCAPRKCB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013004709-A1 | INDOLYLMALEIMIDES AS SOFT PAN-PKC INHIBITORS | AMAKEM NV (BE) | 2013-01-10 | — | — | WO | disclosed |