Known targets — ChEMBL curated mechanism
PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3
The experimentally established mechanism targets of Sotrastaurin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCH known ✓ | P24723 | 20/20 | 0.93 |
| ▸ | PRKCQ known ✓ | Q04759 | 20/20 | 0.93 |
| ▸ | PRKCD known ✓ | Q05655 | 20/20 | 0.93 |
| ▸ | PRKCA known ✓ | P17252 | 19/20 | 0.93 |
| ▸ | PRKCB known ✓ | P05771 | 18/20 | 0.93 |
| ▸ | PRKCE known ✓ | Q02156 | 17/20 | 0.93 |
| ▸ | PRKD3 known ✓ | O94806 | 2/20 | 0.93 |
| ▸ | PRKCG known ✓ | P05129 | 1/20 | 0.93 |
| ▸ | PRKCI known ✓ | P41743 | 1/20 | 0.93 |
| ▸ | PRKCZ known ✓ | Q05513 | 1/20 | 0.93 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.93 |
| ▸ | PIM1 | P11309 | 2/20 | 0.93 |
| ▸ | MARK3 | P27448 | 2/20 | 0.93 |
| ▸ | LTK | P29376 | 2/20 | 0.93 |
| ▸ | GRK5 | P34947 | 2/20 | 0.93 |
| ▸ | KDR | P35968 | 2/20 | 0.93 |
| ▸ | GSK3A | P49840 | 2/20 | 0.93 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.93 |
| ▸ | JAK3 | P52333 | 2/20 | 0.93 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.93 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sotrastaurin SCHEMBL29412439 | 1.00 | PRKCH (0.93) | PRKCHPRKCQPRKCDPRKCAPRKCB | |
| Sotrastaurin SCHEMBL29364923 | 0.96 | PRKCH (1.00) | PRKCHPRKCQPRKCDPRKCAPRKCB | |
| Sotrastaurin SCHEMBL2500835 | 0.96 | PRKCH (1.00) | PRKCHPRKCQPRKCDPRKCAPRKCB | |
| Sotrastaurin SCHEMBL29526075 | 0.96 | PRKCH (1.00) | PRKCHPRKCQPRKCDPRKCAPRKCB | |
| SCHEMBL2493700 | 0.85 | PRKCH (1.00) | PRKCHPRKCQPRKCDPRKCAPRKCB | |
| SCHEMBL31647944 | 0.85 | PRKCH (1.00) | PRKCHPRKCQPRKCDPRKCAPRKCB | |
| SCHEMBL14486643 | 0.84 | PRKCH (0.79) | PRKCHPRKCQPRKCDPRKCAPRKCB | |
| SCHEMBL1994301 | 0.84 | PRKCH (0.78) | PRKCHPRKCQPRKCDPRKCAPRKCB | |
| SCHEMBL4905416 | 0.83 | PRKCH (0.76) | PRKCHPRKCQPRKCDPRKCAPRKCB | |
| Sotrastaurin SCHEMBL26184899 | 0.83 | PRKCH (0.73) | PRKCHPRKCQPRKCDPRKCAPRKCB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2102195-A1 | CRYSTAL MODIFICATIONS -3- (1H-IND0L-3-YL) -4- [2- (4-METHYL-PIPERAZIN-1-YL) -QUINAZOLIN-4-YL]-PYRROLE-2, 5-D IONE | Novartis AG (CH) | 2009-09-23 | — | — | EP | disclosed |
| WO-2008051440-A1 | CRYSTAL MODIFICATIONS -3- (1H-IND0L-3-YL) -4- [2- (4-METHYL-PIPERAZIN-1-YL) -QUINAZOLIN-4-YL] -PYRROLE-2, 5-D IONE | NOVARTIS AG (CH) | 2008-05-02 | — | — | WO | disclosed |