Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.72 |
| ▸ | LMNA | P02545 | 1/20 | 0.72 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.69 |
| ▸ | POLB | P06746 | 1/20 | 0.69 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.69 |
| ▸ | CHIA | Q9BZP6 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.47 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14650526 | 0.90 | MAPT (0.61) | MAPTLMNAL3MBTL1KDM4EPOLB | |
| SCHEMBL12516130 | 0.89 | MAPT (0.72) | MAPTLMNAL3MBTL1KDM4EPOLB | |
| SCHEMBL2222519 | 0.86 | MAPT (0.67) | MAPTLMNAL3MBTL1KDM4EPOLB | |
| SCHEMBL7238484 | 0.85 | CHIA (0.66) | MAPTLMNAL3MBTL1KDM4EPOLB | |
| Hydrochloric Acid SCHEMBL2222043 | 0.85 | MAPT (0.66) | MAPTLMNAL3MBTL1KDM4EPOLB | |
| SCHEMBL2221551 | 0.84 | MAPT (0.66) | MAPTLMNAL3MBTL1KDM4EPOLB | |
| SCHEMBL13089715 | 0.83 | CHIA (0.67) | MAPTLMNAL3MBTL1KDM4EPOLB | |
| SCHEMBL2225986 | 0.83 | MAPT (0.61) | MAPTLMNAL3MBTL1KDM4EPOLB | |
| SCHEMBL2222505 | 0.82 | MAPT (0.63) | MAPTLMNAL3MBTL1KDM4EPOLB | |
| SCHEMBL2223115 | 0.82 | MAPT (0.63) | MAPTLMNAL3MBTL1KDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2729149-A1 | VOLTAGE-GATED SODIUM CHANNEL BLOCKERS | Glaxo Group Limited (GB) | 2014-05-14 | — | — | EP | disclosed |
| WO-2013006596-A1 | VOLTAGE-GATED SODIUM CHANNEL BLOCKERS | GLAXO GROUP LIMITED (GB) | 2013-01-10 | — | — | WO | disclosed |