Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 2/20 | 0.35 |
| ▸ | TOP2B | Q02880 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14499442 | 0.70 | — | — | |
| SCHEMBL17898508 | 0.69 | ALDH1A1 (0.37) | TOP2ATOP2BALDH1A1MAPTTDP1 | |
| SCHEMBL10092705 | 0.68 | — | — | |
| SCHEMBL15764826 | 0.68 | — | — | |
| SCHEMBL10360616 | 0.67 | TOP2A (0.31) | TOP2ATOP2BALDH1A1MAPTTDP1 | |
| SCHEMBL20864922 | 0.67 | — | — | |
| SCHEMBL11670185 | 0.65 | — | — | |
| SCHEMBL1698568 | 0.64 | — | — | |
| SCHEMBL1698543 | 0.62 | ALDH1A1 (0.39) | TOP2ATOP2BALDH1A1MAPTTDP1 | |
| Isopropylamine SCHEMBL28267226 | 0.62 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7235549-B2 | Benzamide, heteroarylamide and reverse amides | PFIZER INC. (US) | 2007-06-26 | — | — | US | disclosed |
| US-7214677-B2 | Benzamide, heteroarylamide and reverse amides | PFIZER INC. (US) | 2007-05-08 | — | — | US | disclosed |