Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 8/20 | 0.63 |
| ▸ | CTSK | P43235 | 7/20 | 0.63 |
| ▸ | CTSB | P07858 | 3/20 | 0.63 |
| ▸ | CTSL | P07711 | 1/20 | 0.63 |
| ▸ | KLKB1 | P03952 | 9/20 | 0.61 |
| ▸ | PSMB1 | P20618 | 3/20 | 0.55 |
| ▸ | PSMB9 | P28065 | 2/20 | 0.55 |
| ▸ | PSMB10 | P40306 | 2/20 | 0.55 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.55 |
| ▸ | PSMB2 | P49721 | 2/20 | 0.55 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.55 |
| ▸ | KLK1 | P06870 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14485327 | 1.00 | CTSS (0.63) | CTSSCTSKCTSBCTSLKLKB1 | |
| SCHEMBL21669918 | 0.92 | KLKB1 (0.57) | CTSSCTSKCTSBCTSLKLKB1 | |
| SCHEMBL14485901 | 0.92 | CTSS (0.74) | CTSSCTSKCTSBCTSL | |
| SCHEMBL14485330 | 0.89 | KLKB1 (0.53) | CTSSCTSKCTSBCTSLKLKB1 | |
| SCHEMBL14485697 | 0.87 | KLKB1 (0.66) | KLKB1KLK1 | |
| SCHEMBL14485701 | 0.87 | KLKB1 (0.66) | KLKB1KLK1 | |
| SCHEMBL17268092 | 0.86 | KLKB1 (0.61) | KLKB1PSMB1PSMB9PSMB10PSMB5 | |
| SCHEMBL15901012 | 0.86 | KLKB1 (0.61) | KLKB1PSMB1PSMB9PSMB10PSMB5 | |
| SCHEMBL14486276 | 0.85 | CTSS (0.59) | CTSSCTSKCTSBCTSLKLKB1 | |
| SCHEMBL14485437 | 0.85 | KLKB1 (0.64) | KLKB1KLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2729443-A1 | BENZYLAMINE DERIVATIVES AS INHIBITORS OF PLASMA KALLIKREIN | Kalvista Pharmaceuticals Limited (GB) | 2014-05-14 | — | — | EP | disclosed |
| WO-2013005045-A1 | BENZYLAMINE DERIVATIVES AS INHIBITORS OF PLASMA KALLIKREIN | KALVISTA PHARMACEUTICALS LIMITED (GB) | 2013-01-10 | — | — | WO | disclosed |