SCHEMBL14489274

SCHEMBL14489274

O=C(O)C(=O)Nc1cc(Cl)c(Oc2ccc(O)c(CC3CCOCC3)c2)c2c1CCC2

nearest known ligand 0.49

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
THRB P10828 17/20 0.49
THRA P10827 14/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5394242 0.90 THRB (0.61) THRBTHRA
SCHEMBL14489337 0.89 THRB (0.48) THRBTHRA
SCHEMBL14489478 0.88 THRB (0.55) THRBTHRA
SCHEMBL14489281 0.83 THRB (0.69) THRBTHRA
SCHEMBL5401287 0.81 THRB (0.56) THRBTHRA
SCHEMBL5407631 0.81 THRB (0.74) THRBTHRA
SCHEMBL14489327 0.81 THRB (0.56) THRBTHRA
SCHEMBL14489397 0.80 THRB (0.58) THRBTHRA
SCHEMBL5400009 0.79 THRB (0.67) THRBTHRA
SCHEMBL14489494 0.79 THRB (0.67) THRBTHRA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7230031-B2 Thyroid hormone receptor ligand, medicinal compositions containing the same and use thereof KISSEI PHARMACEUTICAL CO., LTD. (JP) 2007-06-12 US disclosed
US-7230031-B2 Thyroid hormone receptor ligand, medicinal compositions containing the same and use thereof KISSEI PHARMACEUTICAL CO., LTD. (JP) 2007-06-12 US disclosed