Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 14/20 | 0.50 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.44 |
| ▸ | MAP2K2 | P36507 | 2/20 | 0.44 |
| ▸ | RAF1 | P04049 | 1/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.44 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.44 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.44 |
| ▸ | AURKC | Q9UQB9 | 1/20 | 0.44 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | SMC2 | O95347 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | SMC1A | Q14683 | 1/20 | 0.34 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.34 |
| ▸ | Q6ZSR9 | Q6ZSR9 | 1/20 | 0.34 |
| ▸ | BMP2K | Q9NSY1 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3971404 | 0.93 | MAP2K1 (0.55) | MAP2K1CSNK2A2MAP2K2RAF1PDGFRB | |
| SCHEMBL14489490 | 0.85 | MAP2K1 (0.49) | MAP2K1CSNK2A2MAP2K2RAF1PDGFRB | |
| SCHEMBL13918214 | 0.84 | MAP2K1 (0.53) | MAP2K1CSNK2A2MAP2K2RAF1PDGFRB | |
| SCHEMBL14489498 | 0.84 | MAP2K1 (0.47) | MAP2K1CSNK2A2MAP2K2RAF1PDGFRB | |
| SCHEMBL3979022 | 0.84 | MAP2K1 (0.57) | MAP2K1CSNK2A2MAP2K2RAF1PDGFRB | |
| SCHEMBL3974230 | 0.82 | MAP2K1 (0.54) | MAP2K1CSNK2A2MAP2K2RAF1PDGFRB | |
| SCHEMBL3974106 | 0.80 | MAP2K1 (0.54) | MAP2K1CSNK2A2MAP2K2RAF1PDGFRB | |
| SCHEMBL3974000 | 0.78 | MAP2K1 (0.58) | MAP2K1CSNK2A2MAP2K2RAF1PDGFRB | |
| SCHEMBL3971622 | 0.78 | MAP2K1 (0.54) | MAP2K1CSNK2A2MAP2K2RAF1PDGFRB | |
| SCHEMBL3973489 | 0.78 | MAP2K1 (0.49) | MAP2K1CSNK2A2MAP2K2RAF1PDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7230099-B2 | Heterocyclic inhibitors of MEK and methods of use thereof | ARRAY BIOPHARMA, INC. (US) | 2007-06-12 | — | — | US | disclosed |