Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 9/20 | 0.49 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.42 |
| ▸ | MAP2K2 | P36507 | 2/20 | 0.42 |
| ▸ | RAF1 | P04049 | 1/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.42 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.42 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.42 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.42 |
| ▸ | AURKC | Q9UQB9 | 1/20 | 0.42 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.42 |
| ▸ | CSF1R | P07333 | 5/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.38 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMC2 | O95347 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3971622 | 0.93 | MAP2K1 (0.54) | MAP2K1CSNK2A2MAP2K2RAF1PDGFRB | |
| SCHEMBL14489498 | 0.92 | MAP2K1 (0.47) | MAP2K1CSNK2A2MAP2K2RAF1PDGFRB | |
| SCHEMBL5406685 | 0.86 | MAP2K1 (0.52) | MAP2K1CSNK2A2MAP2K2RAF1PDGFRB | |
| SCHEMBL14489487 | 0.85 | MAP2K1 (0.50) | MAP2K1CSNK2A2MAP2K2RAF1PDGFRB | |
| SCHEMBL3973115 | 0.84 | MAP2K1 (0.51) | MAP2K1CSNK2A2MAP2K2RAF1PDGFRB | |
| SCHEMBL15088154 | 0.84 | MAP2K1 (0.51) | MAP2K1CSNK2A2MAP2K2RAF1PDGFRB | |
| SCHEMBL14499985 | 0.84 | MAP2K1 (0.43) | MAP2K1CSNK2A2MAP2K2RAF1PDGFRB | |
| SCHEMBL13918214 | 0.82 | MAP2K1 (0.53) | MAP2K1CSNK2A2MAP2K2RAF1PDGFRB | |
| SCHEMBL3973358 | 0.82 | MAP2K1 (0.53) | MAP2K1CSNK2A2MAP2K2RAF1PDGFRB | |
| SCHEMBL3979022 | 0.81 | MAP2K1 (0.57) | MAP2K1CSNK2A2MAP2K2RAF1PDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7230099-B2 | Heterocyclic inhibitors of MEK and methods of use thereof | ARRAY BIOPHARMA, INC. (US) | 2007-06-12 | — | — | US | disclosed |