SCHEMBL14492018

SCHEMBL14492018

c1ccc2c(c1)ccc1nc3c(N(c4ccncc4)c4ccncc4)ccc(N(c4ccncc4)c4ccncc4)c3nc12

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PRMT5 O14744 1/20 0.41
PRMT3 O60678 1/20 0.41
CARM1 Q86X55 1/20 0.41
EHMT2 Q96KQ7 1/20 0.41
PRMT6 Q96LA8 1/20 0.41
PRMT1 Q99873 1/20 0.41
WDR77 Q9BQA1 1/20 0.41
CYP3A4 P08684 2/20 0.37
SLC2A1 P11166 1/20 0.35
MAOA P21397 1/20 0.35
ALDH1A1 P00352 5/20 0.35
MAPT P10636 4/20 0.35
KDM4E B2RXH2 3/20 0.35
HPGD P15428 3/20 0.35
ALOX5 P09917 1/20 0.35
RAD52 P43351 1/20 0.34
TDP1 Q9NUW8 2/20 0.33
KMT2A Q03164 2/20 0.33
GAA P10253 1/20 0.33
SLC6A2 P23975 3/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14492010 0.89 PRMT5 (0.44) PRMT5PRMT3CARM1EHMT2PRMT6
SCHEMBL14492017 0.86 KMT2A (0.40) PRMT5PRMT3CARM1EHMT2PRMT6
SCHEMBL14492014 0.84 PRMT5 (0.40) PRMT5PRMT3CARM1EHMT2PRMT6
SCHEMBL14492015 0.83 PRMT5 (0.40) PRMT5PRMT3CARM1EHMT2PRMT6
SCHEMBL14492012 0.82 PRMT5 (0.39) PRMT5PRMT3CARM1EHMT2PRMT6
SCHEMBL14492011 0.81 PRMT5 (0.40) PRMT5PRMT3CARM1EHMT2PRMT6
SCHEMBL14492007 0.81 SLC6A2 (0.37) ALDH1A1MAPTKDM4ERAD52TDP1
SCHEMBL14099531 0.81 SLC6A2 (0.38) CYP3A4ALDH1A1MAPTKDM4EHPGD
SCHEMBL14492013 0.79 CYP3A4 (0.44) PRMT5PRMT3CARM1EHMT2PRMT6
SCHEMBL5470832 0.75 PRMT5 (0.56) PRMT5PRMT3CARM1EHMT2PRMT6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20070132372-A1 AMINE BASED COMPOUND AND ORGANIC ELECTROLUMINESCENCE DEVICE USING THE SAME IDEMITSU KOSAN CO., LTD. (JP) 2007-06-14 US disclosed
US-20070132372-A1 AMINE BASED COMPOUND AND ORGANIC ELECTROLUMINESCENCE DEVICE USING THE SAME IDEMITSU KOSAN CO., LTD. (JP) 2007-06-14 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070132372-A1 AMINE BASED COMPOUND AND ORGANIC ELECTROLUMINESCENCE DEVICE USING THE SAME KCNH2, SLC7A5, KCNH3 PRMT5 3619/4885PRMT3 4611/4885CARM1 4797/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.