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KCNH3

Voltage-gated inwardly rectifying potassium channel KCNH3 · Q9ULD8 · KCNH3 on Sugi Atlas →

15,039 patent compounds predicted against KCNH3, 7,984 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL535908 SCHEMBL535908 1.00 20/20
Hydrochloric Acid Hydrochloric Acid (SCHEMBL541197) 1.00 20/20
SCHEMBL1280999 SCHEMBL1280999 1.00 20/20
SCHEMBL1282204 SCHEMBL1282204 1.00 20/20
SCHEMBL1281719 SCHEMBL1281719 0.97 20/20
Hydrochloric Acid Hydrochloric Acid (SCHEMBL1281689) 1.00 17/20
SCHEMBL540957 SCHEMBL540957 0.86 16/20
SCHEMBL1391524 SCHEMBL1391524 0.70 16/20
SCHEMBL1282182 SCHEMBL1282182 1.00 14/20
SCHEMBL540938 SCHEMBL540938 0.91 13/20
SCHEMBL1391116 SCHEMBL1391116 0.55 13/20
SCHEMBL1390952 SCHEMBL1390952 0.64 12/20
SCHEMBL789845 SCHEMBL789845 0.60 12/20
SCHEMBL793178 SCHEMBL793178 0.57 12/20
SCHEMBL893019 SCHEMBL893019 0.56 12/20
SCHEMBL1391356 SCHEMBL1391356 0.52 12/20
SCHEMBL1391562 SCHEMBL1391562 0.49 11/20
Hydrochloric Acid Hydrochloric Acid (SCHEMBL540609) 0.82 10/20
SCHEMBL1391842 SCHEMBL1391842 0.65 10/20
SCHEMBL893015 SCHEMBL893015 0.55 10/20

Clinical trials — most relevant to KCNH3 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Role of Eplerenone in Reducing Recurrence of Atrial Fibrillation in Patient With Structural Heart Disease PHASE4NOT_YET_RECRUITING
Long-Term Sulfonylurea Response in ABCC8 Neonatal Diabetes (SuResponsSUR) PHASE4UNKNOWN
Effect of Methadone and Hydromorphone on the QT Interval After Anesthesia and Surgery PHASE4RECRUITING
Sulphonylurea Receptor Mutation and Responsiveness to Gliclazide - a Pilot Proof of Concept, Randomised Cross-over Study PHASE4COMPLETED
Long-Term Sulfonylurea Response in KCNJ11 Neonatal Diabetes PHASE4COMPLETED
Effect of Amiodarone on the Procedure Outcome in Long-standing Persistent Atrial Fibrillation Undergoing Pulmonary Vein Antral Isolation PHASE3COMPLETED
Long-term Efficacy Study of Sodium Channel Blocker in LQT3 Patients PHASE2COMPLETED
Mutation-specific Therapy for the Long QT Syndrome PHASE2COMPLETED
Sandostatine® LP and Hyperinsulinism PHASE2COMPLETED
A First-in-Human SAD and MAD Study in Healthy Participants to Evaluate Oral YR011 Tablet PHASE1NOT_YET_RECRUITING
Safety, Blood Levels and Effects of AUT00201 in Patients With MEAK PHASE1COMPLETED
A Phase I, Open-Labeled, Single-Arm, Dose Escalation, Clinical and Pharmacology Study of Dichloroacetate (DCA) in Patients With Recurrent and/or Metastatic Solid Tumours PHASE1COMPLETED
Evaluation of the Effects of KCNQ1 Mutation on Insulin Tolerance and Obsessive Compulsive Features in Long QT Romano-Ward Syndrome Patients. nanUNKNOWN
The Physiological Effects of Human Ether-a-go-go-Related Gene (hERG)Blockade on Metabolism nanCOMPLETED
Qatar Cardiovascular Biorepository of AF Patients nanUNKNOWN
The Involvement of ATP Sensitive Potassium Channel in Migraine Aura and Migraine Pain. nanUNKNOWN
Genetic Analysis of Heart Channelopathies in Brazilian Patients and Their Relatives nanUNKNOWN
Macrolides for KCNJ5 - Mutated Aldosterone-Producing Adenoma (MAPA) nanUNKNOWN
Characteristics of Andersen-Tawil Syndrome nanCOMPLETED
Metabolism of Patients With Genetically Caused Cardiac Arrhythmia nanUNKNOWN
The Effects of the Anesthetic Drug Propofol on the Way the Heart Recovers Between Beats nanCOMPLETED
The Effects of the Anti Nausea Drugs Droperidol and Ondansetron on the Way the Heart Recovers Between Beats nanCOMPLETED
Targeting Potassium Channels to Reprogram Glioblastoma Microenvironment: in Vitro and in Vivo Studies nanUNKNOWN
Genetic Determinants of Sudden Cardiac Death nanCOMPLETED
A Cohort Study on the Prognosis of Neonatal KCNQ2 Gene-associated Epileptic Encephalopathy nanUNKNOWN
Comparison Between Epinephrine and Exercise Test in QT Long Syndrome Patients nanUNKNOWN
Families' Experiences of Paediatric ICC Diagnosis nanUNKNOWN
Feasibility of Improving Risk Stratification in Brugada Syndrome nanCOMPLETED
The Use of Antiarrhythmic Drugs in Pediatrics nanUNKNOWN
Gene Study for Infantile Onset Diabetes nanUNKNOWN

Related proteins — ESM-2 sequence neighbours (a KCNH3 binder may also engage these)

ProteinNameSimilarity
O89047 — 1.000 O89047 →
Q9WVJ0 — 1.000 Q9WVJ0 →
Q9R1T9 — 1.000 Q9R1T9 →
Q9TUI4 — 1.000 Q9TUI4 →
Q9UQ05 — 1.000 Q9UQ05 →
O54853 — 0.997 O54853 →
Q8WNY2 — 0.996 Q8WNY2 →
KCNH2 Voltage-gated inwardly rectifying potassium channel KCNH2 0.994 landscape →
O35219 — 0.993 O35219 →
Q9H252 — 0.993 Q9H252 →
O08962 — 0.992 O08962 →
O08703 — 0.992 O08703 →
KCNQ2 Potassium voltage-gated channel subfamily KQT member 2 0.991 landscape →
Q28969 — 0.991 Q28969 →
Q9TSZ3 — 0.991 Q9TSZ3 →
P50638 — 0.990 P50638 →
Q9TTJ7 — 0.990 Q9TTJ7 →
CACNA1H Voltage-dependent T-type calcium channel subunit alpha-1H 0.990 landscape →
Q9TUX8 — 0.990 Q9TUX8 →
Q9MYS6 — 0.990 Q9MYS6 →
Q8K330 — 0.990 Q8K330 →
O70405 — 0.990 O70405 →
Q5RDS0 — 0.989 Q5RDS0 →
Q80UE6 — 0.989 Q80UE6 →
P19024 — 0.989 P19024 →
Q3TRM4 — 0.989 Q3TRM4 →
Q60700 — 0.989 Q60700 →
Q9JK97 — 0.989 Q9JK97 →
Q566C8 — 0.988 Q566C8 →
KCNA5 Potassium voltage-gated channel subfamily A member 5 0.988 landscape →