Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 8/20 | 0.49 |
| ▸ | MERTK | Q12866 | 6/20 | 0.47 |
| ▸ | AXL | P30530 | 5/20 | 0.46 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | ATR | Q13535 | 1/20 | 0.43 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.40 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.40 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10218052 | 0.89 | MERTK (0.47) | METMERTKAXLL3MBTL3L3MBTL1 | |
| SCHEMBL10218057 | 0.85 | MET (0.56) | METMERTKAXLL3MBTL3L3MBTL1 | |
| SCHEMBL10218064 | 0.85 | MET (0.56) | METMERTKAXLATR | |
| SCHEMBL10217688 | 0.84 | MET (0.56) | METMERTKAXLL3MBTL3L3MBTL1 | |
| SCHEMBL10217451 | 0.82 | MET (0.55) | METMERTKAXLATRSCN9A | |
| SCHEMBL10218012 | 0.81 | MET (0.56) | METMERTKAXLATR | |
| SCHEMBL10217753 | 0.81 | MET (0.51) | METMERTKAXLL3MBTL3L3MBTL1 | |
| SCHEMBL10217455 | 0.80 | MET (0.49) | METMERTKAXLL3MBTL1ATR | |
| SCHEMBL10218028 | 0.80 | MET (0.55) | METMERTKAXLL3MBTL3L3MBTL1 | |
| SCHEMBL10217470 | 0.80 | MET (0.54) | METMERTKAXLL3MBTL3L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7230098-B2 | 2-amino- pyridines and pyrazines additionally substituted witn one or more carbocyclic or heterocyclic groups, e.g., 4-[6-amino-5-(2,6-dichloro-benzyloxy)-pyridin-3-yl]-phenol, for treating many kinds of cancer | SUGEN, INC. (US) | 2007-06-12 | — | — | US | disclosed |
| US-7230098-B2 | 2-amino- pyridines and pyrazines additionally substituted witn one or more carbocyclic or heterocyclic groups, e.g., 4-[6-amino-5-(2,6-dichloro-benzyloxy)-pyridin-3-yl]-phenol, for treating many kinds of cancer | SUGEN, INC. (US) | 2007-06-12 | — | — | US | disclosed |