Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.43 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | KDM4C | Q9H3R0 | 4/20 | 0.37 |
| ▸ | KDM6B | O15054 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KDM4A | O75164 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3818724 | 0.86 | TDP1 (0.44) | TDP1SIRT3HASPINROCK2ROCK1 | |
| SCHEMBL3880004 | 0.82 | KDM4C (0.50) | TDP1SIRT3KDM4CKDM6BKDM4E | |
| SCHEMBL4734614 | 0.81 | CYP2E1 (0.43) | TDP1SIRT3HASPINPKMROCK2 | |
| SCHEMBL18599002 | 0.79 | KDM6B (0.43) | TDP1SIRT3PKMKDM4CKDM6B | |
| SCHEMBL7256409 | 0.79 | SIRT3 (0.39) | TDP1SIRT3HASPINROCK2ROCK1 | |
| SCHEMBL28317597 | 0.77 | TDP1 (0.50) | TDP1SIRT3HASPINROCK2ROCK1 | |
| SCHEMBL15906582 | 0.76 | TSHR (0.39) | TDP1SIRT3CYP11B1CYP11B2KDM4C | |
| SCHEMBL15763685 | 0.75 | TDP1 (0.36) | TDP1SIRT3HASPINROCK2ROCK1 | |
| SCHEMBL11236770 | 0.74 | KDM4C (0.44) | TDP1SIRT3HASPINKDM4CKDM6B | |
| SCHEMBL844847 | 0.74 | CYP2E1 (0.43) | HASPINCYP11B1CYP11B2L3MBTL1SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070142365-A1 | Naphthyridine integrase inhibitors | GSK LLC | 2007-06-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070142365-A1 | Naphthyridine integrase inhibitors | PCNA, SAMHD1, NTPCR | TDP1 327/4885SIRT3 1597/4885HASPIN 786/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.