Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 13/20 | 0.78 |
| ▸ | PRKCA | P17252 | 4/20 | 0.61 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.57 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.48 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7029359 | 1.00 | TOP1 (0.78) | TOP1PRKCAROCK2PRKCQMAP3K5 | |
| SCHEMBL14498680 | 0.97 | TOP1 (0.78) | TOP1PRKCAROCK2 | |
| SCHEMBL14498681 | 0.88 | TOP1 (1.00) | TOP1PRKCA | |
| SCHEMBL7022916 | 0.88 | TOP1 (1.00) | TOP1PRKCA | |
| SCHEMBL29489909 | 0.81 | TOP1 (1.00) | TOP1PRKCAPRKCQ | |
| SCHEMBL6727359 | 0.81 | TOP1 (1.00) | TOP1PRKCAPRKCQ | |
| SCHEMBL5664777 | 0.76 | TOP1 (1.00) | TOP1PRKCA | |
| SCHEMBL5664034 | 0.76 | TOP1 (1.00) | TOP1PRKCAPRKCQ | |
| SCHEMBL5666540 | 0.74 | TOP1 (0.75) | TOP1PRKCAPRKCQ | |
| SCHEMBL7025632 | 0.74 | TOP1 (0.75) | TOP1PRKCAPRKCQ |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7227019-B2 | Process for the preparation of rebeccamycin and analogs thereof | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-06-05 | — | — | US | disclosed |
| US-7227019-B2 | Process for the preparation of rebeccamycin and analogs thereof | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-06-05 | — | — | US | disclosed |