Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 13/20 | 0.78 |
| ▸ | PRKCA | P17252 | 4/20 | 0.61 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.57 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.48 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14498682 | 1.00 | TOP1 (0.78) | TOP1PRKCAROCK2PRKCQMAP3K5 | |
| SCHEMBL14498680 | 0.97 | TOP1 (0.78) | TOP1PRKCAROCK2 | |
| SCHEMBL14498681 | 0.88 | TOP1 (1.00) | TOP1PRKCA | |
| SCHEMBL7022916 | 0.88 | TOP1 (1.00) | TOP1PRKCA | |
| SCHEMBL29489909 | 0.81 | TOP1 (1.00) | TOP1PRKCAPRKCQ | |
| SCHEMBL6727359 | 0.81 | TOP1 (1.00) | TOP1PRKCAPRKCQ | |
| SCHEMBL5664777 | 0.76 | TOP1 (1.00) | TOP1PRKCA | |
| SCHEMBL5664034 | 0.76 | TOP1 (1.00) | TOP1PRKCAPRKCQ | |
| SCHEMBL5666540 | 0.74 | TOP1 (0.75) | TOP1PRKCAPRKCQ | |
| SCHEMBL7025632 | 0.74 | TOP1 (0.75) | TOP1PRKCAPRKCQ |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030083271-A1 | Topoisomerase I selective cytotoxic sugar derivatives of indolopyrrolocarbazoles | BRISTOL-MYERS SQUIBB COMPANY | 2003-05-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030083271-A1 | Topoisomerase I selective cytotoxic sugar derivatives of indolopyrrolocarbazoles | TOP1, TOP2A, TOP2B | TOP1 1/4885PRKCA 1381/4885ROCK2 2973/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.