Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 16/20 | 0.73 |
| ▸ | ADORA1 | P30542 | 13/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | RORC | P51449 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1450138 | 0.89 | ADORA2A (0.80) | ADORA2AADORA1ALDH1A1RORCCYP1A2 | |
| SCHEMBL1449648 | 0.85 | ADORA2A (1.00) | ADORA2AADORA1RORC | |
| SCHEMBL1449619 | 0.84 | ADORA2A (0.73) | ADORA2AADORA1ALDH1A1RORCNPC1 | |
| SCHEMBL1449711 | 0.84 | ADORA2A (0.76) | ADORA2AADORA1ALDH1A1RORCHSD17B10 | |
| SCHEMBL1449950 | 0.84 | ADORA2A (1.00) | ADORA2AADORA1ALDH1A1HSD17B10 | |
| SCHEMBL1449872 | 0.83 | ADORA2A (1.00) | ADORA2AADORA1ALDH1A1CYP1A2CYP2C9 | |
| Cyclopropane SCHEMBL15484598 | 0.82 | ADORA2A (0.81) | ADORA2AADORA1ALDH1A1 | |
| Cyclohexane SCHEMBL15484591 | 0.82 | ADORA2A (0.81) | ADORA2AADORA1ALDH1A1 | |
| SCHEMBL1449841 | 0.82 | ADORA2A (1.00) | ADORA2AADORA1ALDH1A1NPC1RAB9A | |
| SCHEMBL1449536 | 0.81 | ADORA2A (0.78) | ADORA2AADORA1ALDH1A1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1794157-B1 | 2-ACYLAMINOTHIAZOLE DERIVATIVES | LUNDBECK & CO AS H (DK) | 2014-02-26 | — | — | EP | claimed |
| US-7910613-B2 | 2-acylaminothiazole derivatives | H. LUNDBECK A/S (DK) | 2011-03-22 | — | — | US | claimed |
| US-7910613-B2 | 2-acylaminothiazole derivatives | H. LUNDBECK A/S (DK) | 2011-03-22 | — | — | US | disclosed |
| US-7910613-B2 | 2-acylaminothiazole derivatives | H. LUNDBECK A/S (DK) | 2011-03-22 | — | — | US | disclosed |
| US-7910613-B2 | 2-acylaminothiazole derivatives | H. LUNDBECK A/S (DK) | 2011-03-22 | — | — | US | disclosed |
| US-20090137642-A1 | 2-Acylaminothiazole Derivatives | H. LUNDBECK A/S (DK) | 2009-05-28 | — | — | US | disclosed |
| US-20090137642-A1 | 2-Acylaminothiazole Derivatives | H. LUNDBECK A/S (DK) | 2009-05-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090137642-A1 | 2-Acylaminothiazole Derivatives | ADORA2A, HTR2C, ADORA2B | ADORA2A 1/4885ADORA1 7/4885ALDH1A1 446/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.