Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LSS | P48449 | 1/20 | 0.56 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.49 |
| ▸ | LTA4H | P09960 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5639173 | 0.81 | LSS (0.52) | LSSCXCR1LTA4HKDM4EALDH1A1 | |
| SCHEMBL5640125 | 0.81 | LSS (0.54) | LSSCXCR1LTA4HKDM4EALDH1A1 | |
| SCHEMBL5641512 | 0.78 | LSS (0.56) | LSSCXCR1KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL5639061 | 0.78 | LSS (0.51) | LSSCXCR1HRH3 | |
| Hydrochloric Acid SCHEMBL5638788 | 0.78 | ATP4A (0.51) | LSSCXCR1KDM4ESMN1; SMN2 | |
| SCHEMBL5638731 | 0.76 | LSS (0.54) | LSSCXCR1LTA4HKDM4EALDH1A1 | |
| SCHEMBL5640083 | 0.76 | LSS (0.53) | LSSCXCR1KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL5639209 | 0.75 | LSS (0.52) | LSSCXCR1LTA4HKDM4EALDH1A1 | |
| SCHEMBL5639033 | 0.75 | LSS (0.52) | LSSCXCR1LTA4HCACNA1BHRH3 | |
| SCHEMBL10679594 | 0.75 | LSS (1.00) | LSSCXCR1LTA4HKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7229987-B2 | Multicyclic compounds for use as melanin concentrating hormone antagonists in the treatment of obesity and diabetes | ELI LILLY AND COMPANY (US) | 2007-06-12 | — | — | US | disclosed |
| US-7229987-B2 | Multicyclic compounds for use as melanin concentrating hormone antagonists in the treatment of obesity and diabetes | ELI LILLY AND COMPANY (US) | 2007-06-12 | — | — | US | disclosed |