Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 5/20 | 0.71 |
| ▸ | LMNA | P02545 | 4/20 | 0.71 |
| ▸ | NR3C1 | P04150 | 4/20 | 0.71 |
| ▸ | PGR | P06401 | 4/20 | 0.71 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.71 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.71 |
| ▸ | MAPT | P10636 | 3/20 | 0.69 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.69 |
| ▸ | CNR1 | P21554 | 1/20 | 0.69 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.69 |
| ▸ | USP2 | O75604 | 1/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | AR | P10275 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | TNF | P01375 | 2/20 | 0.57 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.55 |
| ▸ | DRD2 | P14416 | 1/20 | 0.55 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.55 |
| ▸ | IKBKB | O14920 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14501158 | 0.93 | HIF1A (0.60) | HIF1ALMNANR3C1PGRCYP3A4 | |
| SCHEMBL14501128 | 0.92 | HIF1A (0.74) | HIF1ALMNANR3C1PGRCYP3A4 | |
| SCHEMBL14501148 | 0.90 | HIF1A (0.71) | HIF1ALMNANR3C1PGRCYP3A4 | |
| Triamcinolone Hexacetonide SCHEMBL21091792 | 0.90 | HIF1A (0.75) | HIF1ALMNANR3C1PGRCYP3A4 | |
| Triamcinolone Hexacetonide SCHEMBL5485022 | 0.90 | HIF1A (0.75) | HIF1ALMNANR3C1PGRCYP3A4 | |
| Triamcinolone Hexacetonide SCHEMBL6835644 | 0.90 | HIF1A (0.75) | HIF1ALMNANR3C1PGRCYP3A4 | |
| Triamcinolone Hexacetonide SCHEMBL7543 | 0.90 | HIF1A (0.75) | HIF1ALMNANR3C1PGRCYP3A4 | |
| SCHEMBL14501054 | 0.90 | HIF1A (0.72) | HIF1ALMNANR3C1PGRCYP3A4 | |
| SCHEMBL12087295 | 0.89 | HIF1A (0.84) | HIF1ALMNANR3C1PGRCYP3A4 | |
| SCHEMBL14501089 | 0.89 | HIF1A (0.71) | HIF1ALMNANR3C1PGRCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7214710-B2 | Permeable, water soluble, non-irritating prodrugs of chemotherapeutic agents with oxaalkanoic acids | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2007-05-08 | — | — | US | disclosed |
| US-7214710-B2 | Permeable, water soluble, non-irritating prodrugs of chemotherapeutic agents with oxaalkanoic acids | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2007-05-08 | — | — | US | disclosed |