Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Triamcinolone Hexacetonide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 known ✓ | P04150 | 4/20 | 0.75 |
| ▸ | HIF1A | Q16665 | 6/20 | 0.75 |
| ▸ | LMNA | P02545 | 5/20 | 0.75 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.75 |
| ▸ | PGR | P06401 | 4/20 | 0.75 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.75 |
| ▸ | MAPT | P10636 | 3/20 | 0.72 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.72 |
| ▸ | CNR1 | P21554 | 1/20 | 0.72 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.72 |
| ▸ | USP2 | O75604 | 1/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.62 |
| ▸ | AR | P10275 | 1/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.62 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.57 |
| ▸ | DRD2 | P14416 | 1/20 | 0.57 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.57 |
| ▸ | IKBKB | O14920 | 1/20 | 0.56 |
| ▸ | JAK2 | O60674 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Triamcinolone Hexacetonide SCHEMBL7543 | 1.00 | HIF1A (0.75) | HIF1ALMNACYP3A4NR3C1PGR | |
| Triamcinolone Hexacetonide SCHEMBL5485022 | 1.00 | HIF1A (0.75) | HIF1ALMNACYP3A4NR3C1PGR | |
| Triamcinolone Hexacetonide SCHEMBL21091792 | 1.00 | HIF1A (0.75) | HIF1ALMNACYP3A4NR3C1PGR | |
| SCHEMBL12087295 | 0.92 | HIF1A (0.84) | HIF1ALMNACYP3A4NR3C1PGR | |
| SCHEMBL19762242 | 0.91 | HIF1A (0.78) | HIF1ALMNACYP3A4NR3C1PGR | |
| SCHEMBL28971361 | 0.90 | HIF1A (0.87) | HIF1ALMNACYP3A4NR3C1PGR | |
| SCHEMBL11422147 | 0.90 | HIF1A (0.87) | HIF1ALMNACYP3A4NR3C1PGR | |
| SCHEMBL15975096 | 0.90 | HIF1A (0.87) | HIF1ALMNACYP3A4NR3C1PGR | |
| SCHEMBL14884636 | 0.90 | HIF1A (0.87) | HIF1ALMNACYP3A4NR3C1PGR | |
| SCHEMBL124165 | 0.90 | HIF1A (0.87) | HIF1ALMNACYP3A4NR3C1PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6753164-B2 | FOR DIAGNOSIS, PROPHYLAXIS AND THERAPY OF CANCER, INFLAMMATION, NEUROLOGICAL DISORDERS AND IMMUNE DISEASES AND/OR DISORDERS | HUMAN GENOME SCIENCES, INC. | 2004-06-22 | — | — | US | disclosed |
| US-20020160491-A1 | Human Serpin polynucleotides, polypeptides, and antibodies | HUMAN GENOME SCIENCES, INC. | 2002-10-31 | — | — | US | disclosed |