Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.46 |
| ▸ | HTR1A | P08908 | 3/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.44 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5383054 | 0.79 | SIGMAR1 (0.48) | SIGMAR1HTR1AOPRM1OPRL1HRH3 | |
| SCHEMBL5904201 | 0.79 | CYP19A1 (0.53) | SIGMAR1HTR1AOPRM1OPRL1HRH3 | |
| SCHEMBL5904101 | 0.78 | SIGMAR1 (0.71) | SIGMAR1HTR1AOPRM1OPRL1HRH3 | |
| SCHEMBL4621851 | 0.78 | CYP19A1 (0.52) | SIGMAR1HTR1AOPRM1OPRL1HRH3 | |
| SCHEMBL5582559 | 0.78 | SIGMAR1 (0.47) | SIGMAR1HTR1AOPRM1OPRL1HRH3 | |
| Bromide SCHEMBL5904342 | 0.78 | CYP19A1 (0.52) | SIGMAR1HTR1AOPRM1OPRL1HRH3 | |
| Hydrochloric Acid SCHEMBL4622114 | 0.77 | CYP19A1 (0.51) | SIGMAR1HTR1AOPRM1OPRL1HRH3 | |
| Hydrochloric Acid SCHEMBL4622628 | 0.76 | SIGMAR1 (0.68) | SIGMAR1HTR1AHRH3MCHR1HRH1 | |
| SCHEMBL14454746 | 0.76 | SIGMAR1 (0.70) | SIGMAR1HTR1AOPRM1OPRL1HRH3 | |
| Hydrochloric Acid SCHEMBL5904107 | 0.76 | HRH3 (0.55) | SIGMAR1HTR1AHRH3HRH1BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7220777-B2 | Lactam derivatives as antagonists for human 11cby receptors | SMITHKLINE BEECHAM P.L.C. (GB) | 2007-05-22 | — | — | US | disclosed |
| US-7220777-B2 | Lactam derivatives as antagonists for human 11cby receptors | SMITHKLINE BEECHAM P.L.C. (GB) | 2007-05-22 | — | — | US | disclosed |