Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 8/20 | 0.71 |
| ▸ | SLC6A4 | P31645 | 8/20 | 0.71 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.71 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.71 |
| ▸ | OPRD1 | P41143 | 5/20 | 0.71 |
| ▸ | SLC22A1 | O15245 | 3/20 | 0.71 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.71 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.71 |
| ▸ | MEN1 | O00255 | 1/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5626717 | 0.88 | SLC6A2 (0.71) | SLC6A2SLC6A4OPRM1OPRK1OPRD1 | |
| SCHEMBL4663225 | 0.88 | SLC6A2 (0.71) | SLC6A2SLC6A4OPRM1OPRK1OPRD1 | |
| SCHEMBL5630256 | 0.88 | SLC6A2 (0.71) | SLC6A2SLC6A4OPRM1OPRK1OPRD1 | |
| Hydrochloric Acid SCHEMBL5348209 | 0.87 | SLC6A2 (0.70) | SLC6A2SLC6A4OPRM1OPRK1OPRD1 | |
| SCHEMBL4665322 | 0.87 | SLC6A2 (0.70) | SLC6A2SLC6A4OPRM1OPRK1OPRD1 | |
| Hydrochloric Acid SCHEMBL4663747 | 0.86 | SLC6A2 (0.69) | SLC6A2SLC6A4OPRM1OPRK1OPRD1 | |
| SCHEMBL4665375 | 0.85 | SLC6A2 (0.67) | SLC6A2SLC6A4OPRM1OPRK1OPRD1 | |
| SCHEMBL8022653 | 0.85 | SLC6A2 (0.67) | SLC6A2SLC6A4OPRM1OPRK1OPRD1 | |
| Hydrochloric Acid SCHEMBL8616513 | 0.84 | SLC6A2 (0.66) | SLC6A2SLC6A4OPRM1OPRK1OPRD1 | |
| Hydrochloric Acid SCHEMBL4663896 | 0.84 | SLC6A2 (0.66) | SLC6A2SLC6A4OPRM1OPRK1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7217729-B2 | Substituted indoles, process for the production thereof and use thereof for combatting pain | GRUNENTHAL GMBH (DE) | 2007-05-15 | — | — | US | disclosed |
| US-7217729-B2 | Substituted indoles, process for the production thereof and use thereof for combatting pain | GRUNENTHAL GMBH (DE) | 2007-05-15 | — | — | US | disclosed |