Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 8/20 | 0.71 |
| ▸ | SLC6A4 | P31645 | 8/20 | 0.71 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.71 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.71 |
| ▸ | OPRD1 | P41143 | 5/20 | 0.71 |
| ▸ | SLC22A1 | O15245 | 3/20 | 0.71 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.71 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.71 |
| ▸ | MEN1 | O00255 | 1/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5626717 | 1.00 | SLC6A2 (0.71) | SLC6A2SLC6A4OPRM1OPRK1OPRD1 | |
| SCHEMBL5630256 | 1.00 | SLC6A2 (0.71) | SLC6A2SLC6A4OPRM1OPRK1OPRD1 | |
| Hydrochloric Acid SCHEMBL5348209 | 0.99 | SLC6A2 (0.70) | SLC6A2SLC6A4OPRM1OPRK1OPRD1 | |
| Butyric Acid SCHEMBL4665884 | 0.90 | OPRD1 (0.59) | SLC6A2SLC6A4OPRM1OPRK1OPRD1 | |
| SCHEMBL14503534 | 0.88 | SLC6A2 (0.71) | SLC6A2SLC6A4OPRM1OPRK1OPRD1 | |
| SCHEMBL4665388 | 0.87 | SLC6A4 (0.55) | SLC6A2SLC6A4OPRM1OPRK1OPRD1 | |
| SCHEMBL4665322 | 0.87 | SLC6A2 (0.70) | SLC6A2SLC6A4OPRM1OPRK1OPRD1 | |
| Hydrochloric Acid SCHEMBL5347029 | 0.86 | SLC6A4 (0.54) | SLC6A2SLC6A4OPRM1OPRK1OPRD1 | |
| Hydrochloric Acid SCHEMBL4663747 | 0.86 | SLC6A2 (0.69) | SLC6A2SLC6A4OPRM1OPRK1OPRD1 | |
| SCHEMBL4665375 | 0.85 | SLC6A2 (0.67) | SLC6A2SLC6A4OPRM1OPRK1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1571140-B1 | C-substituted cyclohexylmethylamine derivatives | GRUENENTHAL GMBH (DE) | 2008-11-12 | — | — | EP | disclosed |
| EP-1571140-B1 | C-substituted cyclohexylmethylamine derivatives | GRUENENTHAL GMBH (DE) | 2008-11-12 | — | — | EP | disclosed |
| US-7273952-B2 | Substituted C-cyclohexylmethylamine derivatives | GRUENENTHAL GMBH (DE) | 2007-09-25 | — | — | US | disclosed |
| US-7273952-B2 | Substituted C-cyclohexylmethylamine derivatives | GRUENENTHAL GMBH (DE) | 2007-09-25 | — | — | US | disclosed |
| US-7273952-B2 | Substituted C-cyclohexylmethylamine derivatives | GRUENENTHAL GMBH (DE) | 2007-09-25 | — | — | US | disclosed |
| US-7168937-B2 | Method for the enzymatic resolution of the racemates of aminomethyl-aryl-cyclohexanol derivatives | GRUENENTHAL GMBH (DE) | 2007-01-30 | — | — | US | disclosed |
| US-7168937-B2 | Method for the enzymatic resolution of the racemates of aminomethyl-aryl-cyclohexanol derivatives | GRUENENTHAL GMBH (DE) | 2007-01-30 | — | — | US | disclosed |
| EP-1368299-B1 | SUBSTITUTED C-CYCLOHEXYLMETHYLAMINE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2006-07-26 | — | — | EP | disclosed |
| US-7041662-B2 | Substituted benzo [b] azepin-2-one compounds | GRUNENTHAL GMBH (DE) | 2006-05-09 | — | — | US | disclosed |
| EP-1444206-B1 | SUBSTITUTED BENZO[B]AZEPIN-2-ONE COMPOUNDS AS ANALGESICS | GRUENENTHAL GMBH (DE) | 2006-03-15 | — | — | EP | disclosed |
| US-20040224954-A1 | Substituted 1H-quinoxalin-2-one compounds and substituted 4-aryl- and 4-heteroarylcyclohexane compounds | GRUNENTHAL GMBH (DE) | 2004-11-11 | — | — | US | disclosed |
| EP-1444212-A1 | SUBSTITUTED (1H)-QUINOXALIN-2-ONE COMPOUNDS AND SUBSTITUTED 4-ARYL- AND 4-HETEROARYLCYCLOHEXANE COMPOUNDS | Grünenthal GmbH (DE) | 2004-08-11 | — | — | EP | disclosed |
| EP-1444206-A1 | SUBSTITUTED BENZO B AZEPIN-2-ONE COMPOUNDS | Grünenthal GmbH (DE) | 2004-08-11 | — | — | EP | disclosed |
| US-20030232891-A1 | Substituted C-cyclohexylmethylamine derivatives | GRUENENTHAL GMBH (DE) | 2003-12-18 | — | — | US | disclosed |
| EP-1368299-A2 | SUBSTITUTED C-CYCLOHEXYLMETHYLAMINE DERIVATIVES | Grünenthal GmbH (DE) | 2003-12-10 | — | — | EP | disclosed |
| WO-2003037879-A1 | SUBSTITUTED (1H)-QUINOXALIN-2-ONE COMPOUNDS AND SUBSTITUTED 4-ARYL- AND 4-HETEROARYLCYCLOHEXANE COMPOUNDS | Grünenthal GmbH (DE) | 2003-05-08 | — | — | WO | disclosed |
| WO-2003037873-A1 | SUBSTITUTED BENZO[B]AZEPIN-2-ONE COMPOUNDS | Grünenthal GmbH (DE) | 2003-05-08 | — | — | WO | disclosed |
| WO-2002030870-A2 | SUBSTITUTED C-CYCLOHEXYLMETHYLAMINE DERIVATIVES | Grünenthal GmbH (DE) | 2002-04-18 | — | — | WO | disclosed |
| EP-0780369-B1 | 1-Phenyl-2-dimethylaminomethyl-cyclohexan-1-ol derivatives as pharmaceutical agents | GRUENENTHAL GMBH (DE) | 2000-01-19 | — | — | EP | disclosed |
| EP-0780369-A1 | 1-Phenyl-2-dimethylaminomethyl-cyclohexan-1-ol derivatives as pharmaceutical agents | Grünenthal GmbH (DE) | 1997-06-25 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030232891-A1 | Substituted C-cyclohexylmethylamine derivatives | CNR2, CNR1, HNMT | SLC6A2 611/4885SLC6A4 358/4885OPRM1 5/4885 |
| US-20040224954-A1 | Substituted 1H-quinoxalin-2-one compounds and substituted 4-aryl- and 4-heteroarylcyclohexane compounds | NQO2, NQO1, CYP2C8 | SLC6A2 1292/4885SLC6A4 1389/4885OPRM1 661/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.