Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.62 |
| ▸ | HPGD | P15428 | 8/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
| ▸ | THRB | P10828 | 1/20 | 0.60 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 7/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.58 |
| ▸ | CNR2 | P34972 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 3/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5432089 | 0.90 | ALDH1A1 (0.66) | ALDH1A1HPGDLMNAKDM4ETP53 | |
| SCHEMBL5434339 | 0.90 | ALDH1A1 (0.66) | ALDH1A1HPGDLMNAKDM4ETP53 | |
| SCHEMBL5444405 | 0.89 | ALDH1A1 (0.65) | ALDH1A1HPGDLMNAKDM4ETP53 | |
| SCHEMBL14505518 | 0.84 | HPGD (0.60) | ALDH1A1HPGDLMNAKDM4ETP53 | |
| SCHEMBL14505526 | 0.83 | CHEK1 (0.53) | ALDH1A1HPGDLMNAKDM4ETP53 | |
| SCHEMBL14505523 | 0.80 | ALDH1A1 (0.57) | ALDH1A1HPGDLMNAKDM4ETP53 | |
| SCHEMBL5435719 | 0.79 | IKBKB (0.46) | ALDH1A1HPGDKDM4EMAPTCNR2 | |
| SCHEMBL1579548 | 0.78 | ALDH1A1 (0.72) | ALDH1A1HPGDLMNAKDM4ETP53 | |
| SCHEMBL14505521 | 0.78 | ALDH1A1 (0.54) | ALDH1A1HPGDLMNAKDM4ETP53 | |
| SCHEMBL5430057 | 0.77 | CNR2 (0.55) | ALDH1A1HPGDLMNAKDM4ETP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070099929-A1 | Substituted thiophenes | AICURIS GMBH & CO. KG (DE) | 2007-05-03 | — | — | US | disclosed |
| US-20070099929-A1 | Substituted thiophenes | AICURIS GMBH & CO. KG (DE) | 2007-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070099929-A1 | Substituted thiophenes | TPMT, HAVCR2, MTAP | ALDH1A1 1246/4885HPGD 2665/4885LMNA 4343/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.