Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 20/20 | 0.78 |
| ▸ | CXCR1 | P25024 | 18/20 | 0.78 |
| ▸ | CCR7 | P32248 | 4/20 | 0.78 |
| ▸ | CCR6 | P51684 | 4/20 | 0.60 |
| ▸ | CXCR3 | P49682 | 3/20 | 0.60 |
| ▸ | CCR4 | P51679 | 3/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12262746 | 0.88 | CXCR2 (1.00) | CXCR2CXCR1CCR7CCR6CXCR3 | |
| SCHEMBL12262779 | 0.84 | CXCR1 (0.93) | CXCR2CXCR1CCR7CCR6CXCR3 | |
| SCHEMBL12086754 | 0.84 | CXCR2 (0.69) | CXCR2CXCR1CCR7CCR6 | |
| SCHEMBL21297010 | 0.84 | CXCR2 (1.00) | CXCR2CXCR1CCR7CCR6CXCR3 | |
| SCHEMBL14895104 | 0.84 | CXCR2 (1.00) | CXCR2CXCR1CCR7CCR6CXCR3 | |
| SCHEMBL13243271 | 0.83 | CXCR2 (0.83) | CXCR2CXCR1CCR7CCR6 | |
| SCHEMBL14894600 | 0.83 | CXCR2 (1.00) | CXCR2CXCR1CCR7CCR6CXCR3 | |
| SCHEMBL20313461 | 0.82 | CXCR1 (0.88) | CXCR2CXCR1CCR7CCR6CXCR3 | |
| SCHEMBL12086856 | 0.81 | CXCR2 (0.78) | CXCR2CXCR1CCR7CCR6 | |
| SCHEMBL14511362 | 0.81 | CXCR2 (0.56) | CXCR2CXCR1CCR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1381590-B1 | 3,4-DI-SUBSTITUTED CYCLOBUTENE-1,2-DIONES AS CXC-CHEMOKINE RECEPTOR LIGANDS | SCHERING CORP (US) | 2007-06-20 | — | — | EP | disclosed |