Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 4/20 | 0.61 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.61 |
| ▸ | PAK4 | O96013 | 15/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | CCR2 | P41597 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10263074 | 1.00 | ROCK2 (0.61) | ROCK2ROCK1PAK4MEN1ALDH1A1 | |
| SCHEMBL14514415 | 0.82 | ROCK2 (0.81) | ROCK2ROCK1CCR2 | |
| SCHEMBL14514413 | 0.82 | ROCK2 (0.81) | ROCK2ROCK1CCR2 | |
| SCHEMBL1716618 | 0.82 | ROCK2 (0.81) | ROCK2ROCK1CCR2 | |
| SCHEMBL26132175 | 0.80 | KMT2A (0.74) | MEN1ALDH1A1MAPK1KMT2ASMN1; SMN2 | |
| SCHEMBL14514431 | 0.79 | ROCK2 (0.72) | ROCK2ROCK1CCR2 | |
| SCHEMBL14514432 | 0.79 | ROCK2 (0.72) | ROCK2ROCK1CCR2 | |
| SCHEMBL14514384 | 0.78 | ROCK2 (0.67) | ROCK2ROCK1MEN1ALDH1A1MAPK1 | |
| SCHEMBL14514385 | 0.78 | ROCK2 (0.67) | ROCK2ROCK1MEN1ALDH1A1MAPK1 | |
| SCHEMBL1716642 | 0.78 | ROCK2 (0.67) | ROCK2ROCK1MEN1ALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7217722-B2 | Nitrogen-containing compounds having kinase inhibitory activity and drugs containing the same | KIRIN BEER KABUSHIKI KAISHA (JP) | 2007-05-15 | — | — | US | disclosed |
| US-7217722-B2 | Nitrogen-containing compounds having kinase inhibitory activity and drugs containing the same | KIRIN BEER KABUSHIKI KAISHA (JP) | 2007-05-15 | — | — | US | disclosed |