Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 12/20 | 0.56 |
| ▸ | SLC2A1 | P11166 | 4/20 | 0.56 |
| ▸ | CDK2 | P24941 | 1/20 | 0.56 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.54 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.54 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.54 |
| ▸ | AURKA | O14965 | 1/20 | 0.51 |
| ▸ | KDR | P35968 | 1/20 | 0.51 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.51 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.51 |
| ▸ | ABL1 | P00519 | 1/20 | 0.45 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | PRKCA | P17252 | 1/20 | 0.45 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13848117 | 0.86 | GSK3B (0.59) | GSK3BSLC2A1CDK2MAPK8MAPK9 | |
| SCHEMBL3441924 | 0.86 | GSK3B (0.58) | GSK3BSLC2A1CDK2MAPK8MAPK9 | |
| SCHEMBL3441920 | 0.85 | MAPK8 (0.60) | GSK3BSLC2A1CDK2MAPK8MAPK9 | |
| SCHEMBL3542608 | 0.84 | EGFR (0.60) | GSK3BSLC2A1CDK2MAPK8MAPK9 | |
| SCHEMBL13105468 | 0.82 | SLC2A1 (0.65) | GSK3BSLC2A1CDK2MAPK8MAPK9 | |
| SCHEMBL3540905 | 0.81 | SLC2A1 (0.65) | GSK3BSLC2A1CDK2MAPK8MAPK9 | |
| SCHEMBL5225447 | 0.81 | SLC2A1 (0.55) | GSK3BSLC2A1CDK2MAPK8MAPK9 | |
| SCHEMBL13848066 | 0.81 | TGFBR1 (0.42) | GSK3BSLC2A1MAPK8MAPK9MAPK10 | |
| SCHEMBL3442634 | 0.81 | SLC2A1 (0.82) | GSK3BSLC2A1CDK2MAPK8MAPK9 | |
| SCHEMBL3441885 | 0.80 | SLC2A1 (0.65) | GSK3BSLC2A1CDK2MAPK8MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1971606-B1 | 2-PYRIMIDINYL PYRAZOLOPYRIDINE ERBB KINASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2013-04-24 | — | — | EP | disclosed |
| WO-2007067506-A2 | 2-PYRIMIDINYL PYRAZOLOPYRIDINE ERBB KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-06-14 | — | — | WO | disclosed |