Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 13/20 | 0.74 |
| ▸ | PTGS1 | P23219 | 13/20 | 0.74 |
| ▸ | PGR | P06401 | 1/20 | 0.56 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.56 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.46 |
| ▸ | MC4R | P32245 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14516364 | 0.88 | PTGS2 (0.64) | PTGS2PTGS1PGRNR3C2ABCB11 | |
| SCHEMBL3247612 | 0.88 | PTGS2 (0.74) | PTGS2PTGS1PGRNR3C2ABCB11 | |
| SCHEMBL3248190 | 0.86 | PTGS1 (1.00) | PTGS2PTGS1ABCB11ALDH1A1MT-CO2 | |
| SCHEMBL14516360 | 0.86 | PTGS1 (1.00) | PTGS2PTGS1ABCB11ALDH1A1MT-CO2 | |
| SCHEMBL4889613 | 0.82 | PTGS2 (0.76) | PTGS2PTGS1ABCB11ALDH1A1MT-CO2 | |
| SCHEMBL3247842 | 0.79 | PTGS2 (0.71) | PTGS2PTGS1ABCB11ALDH1A1MT-CO2 | |
| SCHEMBL14516362 | 0.78 | PTGS2 (0.60) | PTGS2PTGS1ABCB11ALDH1A1MT-CO2 | |
| SCHEMBL3246262 | 0.78 | PTGS2 (0.74) | PTGS2PTGS1ABCB11ALDH1A1MT-CO2 | |
| SCHEMBL5673484 | 0.77 | PTGS2 (0.78) | PTGS2PTGS1ABCB11ALDH1A1MT-CO2 | |
| SCHEMBL12534460 | 0.77 | PTGS2 (0.78) | PTGS2PTGS1ABCB11ALDH1A1MT-CO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7199154-B2 | Nitric oxide releasing prodrugs of diaryl-2-(5h)-furanones as cyclooxygenase-2 inhibitors | MERCK FROSST COMPANY (CA) | 2007-04-03 | — | — | US | disclosed |
| US-7199154-B2 | Nitric oxide releasing prodrugs of diaryl-2-(5h)-furanones as cyclooxygenase-2 inhibitors | MERCK FROSST COMPANY (CA) | 2007-04-03 | — | — | US | disclosed |