Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 5/20 | 0.70 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.65 |
| ▸ | MEN1 | O00255 | 5/20 | 0.65 |
| ▸ | CRHBP | P24387 | 1/20 | 0.65 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.65 |
| ▸ | NTRK3 | Q16288 | 3/20 | 0.64 |
| ▸ | NTRK2 | Q16620 | 3/20 | 0.64 |
| ▸ | RET | P07949 | 3/20 | 0.64 |
| ▸ | SYK | P43405 | 2/20 | 0.64 |
| ▸ | MAPT | P10636 | 2/20 | 0.64 |
| ▸ | KDR | P35968 | 2/20 | 0.64 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.64 |
| ▸ | AURKA | O14965 | 1/20 | 0.64 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.64 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.64 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.64 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.64 |
| ▸ | INSR | P06213 | 1/20 | 0.64 |
| ▸ | LCK | P06239 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7130446 | 0.83 | NTRK1 (0.63) | NTRK1MAP3K5KMT2AMEN1CRHBP | |
| SCHEMBL5469785 | 0.83 | NTRK1 (1.00) | NTRK1MAP3K5KMT2AMEN1CRHBP | |
| SCHEMBL5469776 | 0.83 | NTRK1 (1.00) | NTRK1MAP3K5KMT2AMEN1CRHBP | |
| SCHEMBL14448833 | 0.83 | NTRK1 (1.00) | NTRK1MAP3K5KMT2AMEN1CRHBP | |
| SCHEMBL10095165 | 0.79 | KMT2A (1.00) | NTRK1MAP3K5KMT2AMEN1CRHBP | |
| Gw441756X SCHEMBL5787769 | 0.78 | KMT2A (1.00) | NTRK1MAP3K5KMT2AMEN1CRHBP | |
| Gw441756X SCHEMBL29794620 | 0.78 | KMT2A (1.00) | NTRK1MAP3K5KMT2AMEN1CRHBP | |
| Gw441756X SCHEMBL16196749 | 0.78 | KMT2A (1.00) | NTRK1MAP3K5KMT2AMEN1CRHBP | |
| Gw441756X SCHEMBL5787774 | 0.78 | KMT2A (1.00) | NTRK1MAP3K5KMT2AMEN1CRHBP | |
| Gw441756X SCHEMBL29435064 | 0.78 | KMT2A (1.00) | NTRK1MAP3K5KMT2AMEN1CRHBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7202265-B2 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | SUGEN, INC. (US) | 2007-04-10 | — | — | US | disclosed |
| US-7202265-B2 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | SUGEN, INC. (US) | 2007-04-10 | — | — | US | disclosed |