Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 5/20 | 0.63 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.61 |
| ▸ | MEN1 | O00255 | 6/20 | 0.61 |
| ▸ | CRHBP | P24387 | 1/20 | 0.61 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.61 |
| ▸ | NTRK3 | Q16288 | 3/20 | 0.58 |
| ▸ | NTRK2 | Q16620 | 3/20 | 0.58 |
| ▸ | SYK | P43405 | 2/20 | 0.58 |
| ▸ | FCER2 | P06734 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 4/20 | 0.57 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.57 |
| ▸ | AURKA | O14965 | 1/20 | 0.57 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.57 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.57 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.57 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.57 |
| ▸ | INSR | P06213 | 1/20 | 0.57 |
| ▸ | LCK | P06239 | 1/20 | 0.57 |
| ▸ | CDK1 | P06493 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5357589 | 0.85 | KMT2A (0.64) | NTRK1MAP3K5KMT2AMEN1CRHBP | |
| SCHEMBL7133179 | 0.83 | KMT2A (0.60) | NTRK1MAP3K5KMT2AMEN1CRHBP | |
| SCHEMBL14519086 | 0.83 | NTRK1 (0.70) | NTRK1MAP3K5KMT2AMEN1CRHBP | |
| SCHEMBL7132935 | 0.78 | MEN1 (0.56) | KMT2AMEN1RETIGF1RKDR | |
| SCHEMBL5359703 | 0.78 | RET (0.37) | NTRK1MAP3K5KMT2AMEN1NTRK3 | |
| SCHEMBL14448833 | 0.77 | NTRK1 (1.00) | NTRK1MAP3K5KMT2AMEN1CRHBP | |
| SCHEMBL5469776 | 0.77 | NTRK1 (1.00) | NTRK1MAP3K5KMT2AMEN1CRHBP | |
| SCHEMBL5469785 | 0.77 | NTRK1 (1.00) | NTRK1MAP3K5KMT2AMEN1CRHBP | |
| SCHEMBL10095165 | 0.77 | KMT2A (1.00) | NTRK1MAP3K5KMT2AMEN1CRHBP | |
| SCHEMBL7131400 | 0.76 | MEN1 (0.42) | KMT2AMEN1RETPIM1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6506763-B2 | Useful in prevention and treatment of protein kinase related disorders such as cancer | SUGEN, INC. | 2003-01-14 | — | — | US | disclosed |