Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGIR | P43119 | 1/20 | 0.58 |
| ▸ | BRAF | P15056 | 6/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | CSNK1D | P48730 | 4/20 | 0.57 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.57 |
| ▸ | CSNK1E | P49674 | 3/20 | 0.57 |
| ▸ | MAPK3 | P27361 | 3/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.57 |
| ▸ | BMPR1B | O00238 | 2/20 | 0.57 |
| ▸ | CIT | O14578 | 2/20 | 0.57 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.57 |
| ▸ | STK10 | O94804 | 2/20 | 0.57 |
| ▸ | ABL1 | P00519 | 2/20 | 0.57 |
| ▸ | RAF1 | P04049 | 2/20 | 0.57 |
| ▸ | ERBB3 | P21860 | 2/20 | 0.57 |
| ▸ | JAK1 | P23458 | 2/20 | 0.57 |
| ▸ | ACVR1B | P36896 | 2/20 | 0.57 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.57 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27716525 | 1.00 | PTGIR (0.58) | PTGIRBRAFMEN1KMT2ACSNK1D | |
| SCHEMBL11484651 | 0.92 | PTGIR (0.66) | PTGIRBRAFMEN1KMT2ACSNK1D | |
| SCHEMBL17088198 | 0.87 | BRAF (0.60) | BRAFMEN1KMT2ACSNK1DMAP4K4 | |
| SCHEMBL6077523 | 0.85 | CSNK1D (0.65) | BRAFMEN1KMT2ACSNK1DMAP4K4 | |
| SCHEMBL1892201 | 0.85 | CSNK1D (0.65) | BRAFMEN1KMT2ACSNK1DMAP4K4 | |
| SCHEMBL17088200 | 0.85 | MEN1 (0.62) | BRAFMEN1KMT2ACSNK1DMAP4K4 | |
| SCHEMBL12461241 | 0.85 | BRAF (0.53) | PTGIRBRAFMEN1KMT2ACSNK1D | |
| SCHEMBL11495249 | 0.84 | PTGIR (0.68) | PTGIRBRAFMEN1KMT2ACSNK1D | |
| SCHEMBL17088202 | 0.84 | PDE10A (0.57) | MEN1KMT2APDE10A | |
| SCHEMBL17088199 | 0.80 | MEN1 (0.66) | BRAFMEN1KMT2ACSNK1DMAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070078146-A1 | Antiinflamamtory agents; antiarthritic agents; inflammatory bowel disorders; multiple sclerosis; asthma | PHARMACIA CORPORATION | 2007-04-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070078146-A1 | Antiinflamamtory agents; antiarthritic agents; inflammatory bowel disorders; multiple sclerosis; asthma | MAPK1, MAPK3, MAPK4 | PTGIR 98/4885BRAF 897/4885MEN1 3032/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.