Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.66 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.55 |
| ▸ | BRAF | P15056 | 4/20 | 0.54 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.53 |
| ▸ | BMPR1B | O00238 | 2/20 | 0.53 |
| ▸ | CIT | O14578 | 2/20 | 0.53 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.53 |
| ▸ | STK10 | O94804 | 2/20 | 0.53 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.53 |
| ▸ | ABL1 | P00519 | 2/20 | 0.53 |
| ▸ | RAF1 | P04049 | 2/20 | 0.53 |
| ▸ | ERBB3 | P21860 | 2/20 | 0.53 |
| ▸ | JAK1 | P23458 | 2/20 | 0.53 |
| ▸ | ACVR1B | P36896 | 2/20 | 0.53 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.53 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.53 |
| ▸ | CSNK1E | P49674 | 2/20 | 0.53 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.53 |
| ▸ | MAP2K5 | Q13163 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17088989 | 0.91 | MEN1 (0.64) | MEN1KMT2ASLC6A3BRAFPDE10A | |
| SCHEMBL17088197 | 0.89 | SLC6A3 (0.69) | SLC6A3PDE10A | |
| SCHEMBL17088195 | 0.89 | SLC6A3 (0.69) | SLC6A3PDE10A | |
| SCHEMBL17088189 | 0.84 | MAPK13 (0.63) | BRAFPDE10ACSNK1DCSNK1E | |
| SCHEMBL17088192 | 0.84 | MAPK13 (0.63) | BRAFPDE10ACSNK1DCSNK1E | |
| SCHEMBL17088202 | 0.83 | PDE10A (0.57) | MEN1KMT2ASLC6A3PDE10A | |
| SCHEMBL17088200 | 0.83 | MEN1 (0.62) | MEN1KMT2ASLC6A3BRAFPDE10A | |
| SCHEMBL11996180 | 0.82 | PDE10A (0.61) | SLC6A3PDE10A | |
| SCHEMBL17088198 | 0.81 | BRAF (0.60) | MEN1KMT2ASLC6A3BRAFPDE10A | |
| SCHEMBL1759065 | 0.81 | SLC6A3 (0.83) | MEN1KMT2ASLC6A3PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9138494-B2 | Radiolabeled PDE10A ligands | ABBVIE INC. (US) | 2015-09-22 | — | — | US | disclosed |