Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.48 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | CYP24A1 | Q07973 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | ALPI | P09923 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | XIAP | P98170 | 1/20 | 0.42 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8910360 | 1.00 | MAPT (0.55) | MAPTALDH1A1MEN1KMT2AOPRK1 | |
| SCHEMBL20849755 | 0.87 | MAPT (0.46) | MAPTALDH1A1MEN1KMT2AOPRK1 | |
| SCHEMBL20849762 | 0.87 | MAPT (0.46) | MAPTALDH1A1MEN1KMT2AOPRK1 | |
| SCHEMBL20363249 | 0.86 | MAOB (0.57) | PTGS1 | |
| SCHEMBL14664156 | 0.83 | MME (0.44) | MAPTALDH1A1MEN1KMT2AOPRM1 | |
| SCHEMBL121727 | 0.82 | MAPT (0.61) | MAPTALDH1A1MEN1KMT2AHPGD | |
| SCHEMBL121728 | 0.82 | MAPT (0.61) | MAPTALDH1A1MEN1KMT2AHPGD | |
| SCHEMBL756362 | 0.82 | MAPT (0.61) | MAPTALDH1A1MEN1KMT2AHPGD | |
| SCHEMBL12341937 | 0.80 | ALDH1A1 (0.59) | MAPTALDH1A1MEN1KMT2AHPGD | |
| SCHEMBL8605469 | 0.80 | ALDH1A1 (0.59) | MAPTALDH1A1MEN1KMT2AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7199265-B2 | Thyroid receptor ligands, pharmaceutical compositions comprising them and their use in the treatment of disorders influenced by thyroid hormones | KARO BIO AB (SE) | 2007-04-03 | — | — | US | disclosed |
| US-7199265-B2 | Thyroid receptor ligands, pharmaceutical compositions comprising them and their use in the treatment of disorders influenced by thyroid hormones | KARO BIO AB (SE) | 2007-04-03 | — | — | US | disclosed |