Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1B | P28222 | 2/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 12/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | MITF | O75030 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14525249 | 0.93 | HTR1B (0.68) | HTR1BKCNH2NPC1SMN1; SMN2 | |
| SCHEMBL14525323 | 0.91 | HTR1B (0.62) | HTR1BKCNH2MAPTKDM4ENAMPT | |
| SCHEMBL14525289 | 0.90 | HTR1B (0.61) | HTR1BKCNH2NPC1SMN1; SMN2 | |
| SCHEMBL14525248 | 0.89 | HTR1B (0.74) | HTR1BKCNH2MAPTEPHX2ALDH1A1 | |
| SCHEMBL14525372 | 0.89 | HTR1B (0.62) | HTR1BKCNH2MAPTKDM4ENAMPT | |
| SCHEMBL4246690 | 0.88 | HTR1B (0.62) | HTR1BKCNH2MAPTKDM4EEPHX2 | |
| SCHEMBL14530405 | 0.88 | HTR1B (0.60) | HTR1BKCNH2MAPTPOLBNPC1 | |
| SCHEMBL4246743 | 0.86 | HTR1B (0.80) | HTR1BKCNH2MAPTKDM4EEPHX2 | |
| SCHEMBL14525320 | 0.86 | HTR1B (0.60) | HTR1BKCNH2NPC1SMN1; SMN2 | |
| SCHEMBL14525296 | 0.85 | HTR1B (0.64) | HTR1BKCNH2MAPTEPHX2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007053095-A1 | CHROMAN COMPOUNDS AS 5-HT1B ANTAGONISTS | ASTRAZENECA AB (SE) | 2007-05-10 | — | — | WO | disclosed |