Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1B | P28222 | 1/20 | 0.68 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.68 |
| ▸ | RAB9A | P51151 | 11/20 | 0.41 |
| ▸ | NPC1 | O15118 | 10/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | RAD52 | P43351 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 4/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 4/20 | 0.39 |
| ▸ | RELA | Q04206 | 4/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14525248 | 0.96 | HTR1B (0.74) | HTR1BKCNH2RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL14525323 | 0.95 | HTR1B (0.62) | HTR1BKCNH2RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL14525289 | 0.93 | HTR1B (0.61) | HTR1BKCNH2RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL14525309 | 0.93 | HTR1B (0.60) | HTR1BKCNH2NPC1SMN1; SMN2 | |
| SCHEMBL14525320 | 0.93 | HTR1B (0.60) | HTR1BKCNH2RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL14525372 | 0.93 | HTR1B (0.62) | HTR1BKCNH2RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL14530405 | 0.91 | HTR1B (0.60) | HTR1BKCNH2RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL14529930 | 0.90 | HTR1B (0.57) | HTR1BKCNH2RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL14526630 | 0.90 | HTR1B (0.65) | HTR1BKCNH2SMN1; SMN2RAD52 | |
| SCHEMBL14529629 | 0.89 | HTR1B (0.58) | HTR1BKCNH2RAB9ANPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007053095-A1 | CHROMAN COMPOUNDS AS 5-HT1B ANTAGONISTS | ASTRAZENECA AB (SE) | 2007-05-10 | — | — | WO | disclosed |