Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 16/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14525371 | 0.88 | MAOA (0.72) | MAOAKCNH2CYP3A4CYP2D6 | |
| SCHEMBL5657622 | 0.88 | MAOA (0.72) | MAOAKCNH2CYP3A4CYP2D6 | |
| SCHEMBL5656542 | 0.88 | MAOA (0.61) | MAOAKCNH2CYP3A4CYP2D6 | |
| SCHEMBL14525375 | 0.88 | MAOA (0.61) | MAOAKCNH2CYP3A4CYP2D6 | |
| SCHEMBL4014908 | 0.85 | MAOA (0.71) | MAOAKCNH2CYP3A4CYP2D6 | |
| SCHEMBL13939803 | 0.85 | MAOA (0.71) | MAOAKCNH2CYP3A4CYP2D6 | |
| SCHEMBL13939804 | 0.84 | MAOA (0.46) | MAOA | |
| SCHEMBL6402389 | 0.84 | MAOA (0.58) | MAOAKCNH2CYP3A4CYP2D6 | |
| SCHEMBL5658912 | 0.84 | MAOA (0.58) | MAOAKCNH2CYP3A4CYP2D6 | |
| SCHEMBL14525365 | 0.83 | MAOA (0.59) | MAOAKCNH2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7199143-B2 | Chemical compounds | ASTRAZENECA AB (SE) | 2007-04-03 | — | — | US | disclosed |
| US-7199143-B2 | Chemical compounds | ASTRAZENECA AB (SE) | 2007-04-03 | — | — | US | disclosed |