Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.76 |
| ▸ | NR3C2 | P08235 | 4/20 | 0.76 |
| ▸ | HSD11B2 | P80365 | 3/20 | 0.76 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.76 |
| ▸ | HIF1A | Q16665 | 7/20 | 0.72 |
| ▸ | LMNA | P02545 | 6/20 | 0.72 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.72 |
| ▸ | SHBG | P04278 | 5/20 | 0.72 |
| ▸ | SERPINA6 | P08185 | 5/20 | 0.72 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.72 |
| ▸ | TSHR | P16473 | 3/20 | 0.72 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.72 |
| ▸ | MAPT | P10636 | 3/20 | 0.72 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.72 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.72 |
| ▸ | BLM | P54132 | 1/20 | 0.72 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.72 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.72 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.72 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20058563 | 1.00 | SMN1; SMN2 (0.76) | SMN1; SMN2NR3C2HSD11B2HSD11B1HIF1A | |
| SCHEMBL13752954 | 1.00 | SMN1; SMN2 (0.76) | SMN1; SMN2NR3C2HSD11B2HSD11B1HIF1A | |
| SCHEMBL10185506 | 1.00 | SMN1; SMN2 (0.76) | SMN1; SMN2NR3C2HSD11B2HSD11B1HIF1A | |
| SCHEMBL15920491 | 1.00 | SMN1; SMN2 (0.76) | SMN1; SMN2NR3C2HSD11B2HSD11B1HIF1A | |
| SCHEMBL3362406 | 1.00 | SMN1; SMN2 (0.76) | SMN1; SMN2NR3C2HSD11B2HSD11B1HIF1A | |
| SCHEMBL619054 | 1.00 | SMN1; SMN2 (0.76) | SMN1; SMN2NR3C2HSD11B2HSD11B1HIF1A | |
| SCHEMBL24900243 | 1.00 | SMN1; SMN2 (0.76) | SMN1; SMN2NR3C2HSD11B2HSD11B1HIF1A | |
| SCHEMBL20058468 | 1.00 | SMN1; SMN2 (0.76) | SMN1; SMN2NR3C2HSD11B2HSD11B1HIF1A | |
| SCHEMBL619055 | 1.00 | SMN1; SMN2 (0.76) | SMN1; SMN2NR3C2HSD11B2HSD11B1HIF1A | |
| SCHEMBL3235812 | 1.00 | SMN1; SMN2 (0.76) | SMN1; SMN2NR3C2HSD11B2HSD11B1HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070093460-A1 | Methods of using selective 11beta-HSD inhibitors to treat gluocorticoid associated states | RHODE ISLAND HOSPITAL, THE | 2007-04-26 | — | — | US | disclosed |
| US-20070093460-A1 | Methods of using selective 11beta-HSD inhibitors to treat gluocorticoid associated states | RHODE ISLAND HOSPITAL, THE | 2007-04-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070093460-A1 | Methods of using selective 11beta-HSD inhibitors to treat gluocorticoid associated states | HSD11B2, HSD11B1, HSD17B2 | SMN1; SMN2 2298/4885NR3C2 16/4885HSD11B2 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.